Heart, Lung and Circulation
Volume 15, Issue 1 , Pages 30-37 , February 2006

Atrial Distribution of Connexin 40 and 43 in Patients with Intermittent, Persistent, and Postoperative Atrial Fibrillation

  • Matthias Wilhelm, MD

      Affiliations

    • Department of Cardiology, University of Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 9131 8535301; fax: +49 9131 8535302.
  • ,
  • Wolfgang Kirste

      Affiliations

    • Department of Cardiology, University of Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany
  • ,
  • Simone Kuly, MD

      Affiliations

    • Department of Cardiology, University of Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany
  • ,
  • Kerstin Amann, MD

      Affiliations

    • Institute of Pathology, University of Erlangen, Germany
  • ,
  • Winfried Neuhuber, MD

      Affiliations

    • Institute of Anatomy, University of Erlangen, Germany
  • ,
  • Michael Weyand, MD

      Affiliations

    • Department of Cardiac Surgery, University of Erlangen, Germany
  • ,
  • Werner Günther Daniel, MD

      Affiliations

    • Department of Cardiology, University of Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany
  • ,
  • Christoph Garlichs, MD

      Affiliations

    • Department of Cardiology, University of Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany

References 

  1. Kannel WB, Abbott RD, Savage DD, McNamara PM. Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med. 1982;306:1018–1022
  2. Ryder KM, Benjamin EJ. Epidemiology and significance of atrial fibrillation. Am J Cardiol. 1999;84:131R–138R
  3. Aranki SF, Shaw DP, Adams DH. Predictors of atrial fibrillation after coronary artery surgery. Current trends and impact on hospital resources. Circulation. 1996;94:390–397
  4. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation. 1995;92:1954–1968
  5. Morillo CA, Klein GJ, Jones DL, Guiraudon CM. Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation. 1995;91:1588–1595
  6. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res. 1999;44:121–131
  7. Nattel S. Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation. Cardiovasc Res. 1999;42:298–308
  8. Yue L, Feng J, Gaspo R, Li GR, Wang Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res. 1997;81:512–525
  9. Yue L, Melnyk P, Gaspo R, Wang Z, Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res. 1999;84:776–784
  10. Goette A, Honeycutt C, Langberg JJ. Electrical remodeling in atrial fibrillation. Time course and mechanisms. Circulation. 1996;94:2968–2974
  11. Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res. 2002;54:230–246
  12. Ausma J, Wijffels M, Thone F, Wouters L, Allessie M, Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat. Circulation. 1997;96:3157–3163
  13. Tieleman RG, Crijns HJ. The ‘second factor’ of tachycardia-induced atrial remodeling. Cardiovasc Res. 2000;46:364–366
  14. van der Velden HM, Ausma J, Rook MB. Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat. Cardiovasc Res. 2000;46:476–486
  15. Saffitz JE, Yamada KA. Closing the gap in understanding the regulation of intercellular communication. Cardiovasc Res. 2000;45:807–809
  16. Gros D, Jarry-Guichard T, ten Velde I. Restricted distribution of connexin 40, a gap junctional protein, in mammalian heart. Circ Res. 1994;74:839–851
  17. Vozzi C, Dupont E, Coppen SR, Yeh HI, Severs NJ. Chamber-related differences in connexin expression in the human heart. J Mol Cell Cardiol. 1999;31:991–1003
  18. Beblo DA, Wang HZ, Beyer EC, Westphale EM, Veenstra RD. Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin 40. Circ Res. 1995;77:813–822
  19. Severs NJ. Pathophysiology of gap junctions in heart disease. J Cardiovasc Electrophysiol. 1994;5:462–475
  20. Davis LM, Kanter HL, Beyer EC, Saffitz JE. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol. 1994;24:1126–1132
  21. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE. Gap junction protein phenotypes of the human heart and conduction system. Cardiovasc Electrophysiol. 1996;7:383–385
  22. Saffitz JE, Schuessler RB, Yamada KA. Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias. Cardiovasc Res. 1999;42:309–317
  23. van der Velden HM, van Kempen MJ, Wijffels MC. Altered pattern of connexin 40 distribution in persistent atrial fibrillation in the goat. J Cardiovasc Electrophysiol. 1998;9:596–607
  24. Dupont E, Ko Y, Rothery S, Coppen SR. The gap-junctional protein connexin 40 is elevated in patients susceptible to postoperative atrial fibrillation. Circulation. 2001;103:842–849
  25. Kostin S, Klein G, Szalay Z, Hein S, Bauer EP, Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovasc Res. 2002;54:361–379
  26. Nao T, Ohkusa T, Hisamatsu Y. Comparison of expression of connexin in right atrial myocardium in patients with chronic atrial fibrillation versus those in sinus rhythm. Am J Cardiol. 2003;91:678–683
  27. Polontchouk L, Haefliger JA, Ebelt B. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. J Am Coll Cardiol. 2001;38:883–891
  28. Fitzmaurice M, Bordagaray JO, Engelmann GL. Argon ion laser-excited autofluorescence in normal and atherosclerotic aorta and coronary arteries: morphologic studies. Am Heart J. 1989;118:1028–1038
  29. Laird DW, Puranam KL, Revel JP. Turnover and phosphorylation dynamics of connexin 43 gap junction protein in cultured cardiac myocytes. Biochem J. 1991;273:67–72
  30. Beardslee MA, Laing JG, Beyer EC, Saffitz JE. Rapid turnover of connexin 43 in the adult rat heart. Circ Res. 1998;83:629–635
  31. Laing JG, Tadros PN, Westphale EM, Beyer EC. Degradation of connexin 43 gap junctions involves both the proteasome and the lysosome. Exp Cell Res. 1997;236:482–492
  32. Saffitz JE, Laing JG, Yamada KA. Connexin expression and turnover: implications for cardiac excitability. Circ Res. 2000;86:723–728
  33. Ausma J, van der Velden HM, Lenders MH. Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat. Circulation. 2003;107:2051–2058
  34. Creswell LL, Schuessler RB, Rosenbloom M, Cox JL. Hazards of postoperative atrial arrhythmias. Ann Thorac Surg. 1993;56:539–549
  35. Ducceschi V, D’Andrea A, Liccardo B. Perioperative clinical predictors of atrial fibrillation occurrence following coronary artery surgery. Eur J Cardiothorac Surg. 1999;16:435–439
  36. Roy D, Talajic M, Dorian P, Connolly S. Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators. N Engl J Med. 2000;342:913–920
  37. Dhein S, Polontchouk L, Salameh A, Haefliger JA. Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40. Biol Cell. 2002;94:409–422
  38. Kaprielian R, Gunning M, Dupont E. Downregulation of immunodectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation. 1998;97:651–660

PII: S1443-9506(05)00136-8

doi: 10.1016/j.hlc.2005.06.011

Heart, Lung and Circulation
Volume 15, Issue 1 , Pages 30-37 , February 2006