Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 139-142 , April 2006

Sildenafil as Adjunct Therapy to High-Dose Epoprostenol in a Patient with Pulmonary Veno-Occlusive Disease

  • Tadashi Kuroda, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Hisao Hirota, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Mitsuru Masaki, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Shoko Sugiyama, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Yuichi Oshima, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Kazuo Terai, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Akihiko Ito, MD

      Affiliations

    • Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Keiko Yamauchi-Takihara, MD

      Affiliations

    • Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 6 6879 3835; fax: +81 6 6879 3839.

References 

  1. Holcomb BW, Loyd JE, Ely EW, Johnson J, Robbins IM. Pulmonary veno-occlusive disease: a case series and new observations. Chest. 2000;118:1671–1679
  2. Palmer SM, Robinson LJ, Wang A, Gossage JR, Bashore T, Tapson VF. Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease. Chest. 1998;113:237–240
  3. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation. 2002;105:2398–2403
  4. Okumura H, Nagaya N, Kyotani S, Sakamaki F, Nakanishi F, Fukuhara S, et al. Effects of continuous iv prostacyclin in a patient with pulmonary veno-occlusive disease. Chest. 2002;122:1096–1098
  5. Davis LL, deBoisblane BP, Glynn CE, Ramirez C, Summer WR. Effect of prostacyclin on microvascular pressures in a patient with pulmonary veno-occlusive disease. Chest. 1995;108:1754–1756
  6. Eckly AE, Lugnier C. Role of phosphodiesterase III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway. Br J Pharmacol. 1994;113:445–450

PII: S1443-9506(05)00153-8

doi: 10.1016/j.hlc.2005.07.002

Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 139-142 , April 2006

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