Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 124-129 , April 2006

Apoptosis-Related Gene Bcl-2 in Lung Tissue After Experimental Traumatic Brain Injury in Rats

  • Erkan Yildirim, MD, FETCS

      Affiliations

    • Thoracic Division, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 312 310 30 30/3004–3005; fax: +90 312 484 62 04; mobile: +90 532 445 39 38.
    • ,
  • Kanat Ozisik, MD

      Affiliations

    • Department of Cardiovascular Surgery, Ankara Numune Teaching and Research Hospital, Ankara, Turkey
    • ,
  • Pinar Ozisik, MD

      Affiliations

    • Hacettepe University, Institute of Neurological Sciences and Psychiatry, Ankara, Turkey
    • ,
  • Mustafa Emir, MD

      Affiliations

    • Department of Cardiovascular Surgery, TYIH, Ankara, Turkey
    • ,
  • Engin Yildirim, MD

      Affiliations

    • Department of Pharmacology, School of Medicine, Osmangazi University, Eskişehir, Turkey
    • ,
  • Müge Misirlioglu, PhD

      Affiliations

    • Metis Biotechnology, Ltd., Ankara, Turkey
    • ,
  • Serdar Tuncer, MD

      Affiliations

    • Metis Biotechnology, Ltd., Ankara, Turkey
    • ,
  • Kamer Kilinc, MD

      Affiliations

    • Department of Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Received 22 May 2005 ,Revised 2 October 2005 ,Accepted 3 October 2005.

References 

  1. Yildirim E, Kaptanoglu E, Ozisik K, Beskonakli E, Okutan O, Sargon MF, et al. Ultrastructural changes in pneumocyte type II cells following traumatic brain injury in rats. Eur J Cardiothorac Surg. 2004;25:523–529
  2. Raghupathi R, Strauss KI, Zhang C, Krajewski S, Reed JC, McIntosh TK. Temporal alterations in cellular Bax: Bcl-2 ratio following traumatic brain injury in the rat. J Neurotrauma. 2003;20(5):421–435
  3. Felderhoff-Mueser U, Sifringer M, Pesditschek S, Kuckuck H, Moysich A, Bittigau P, et al. Pathways leading to apoptotic neurodegeneration following trauma to the developing rat brain. Neurobiol Dis. 2002;11(2):231–245
  4. Yang X, Yang S, Zhang J, Xue L. Expression and significance of Bcl-2 and Bcl-xL in rat neuron after acute brain trauma. Zhonghua Wai Ke Za Zhi. 2002;40(9):702–704
  5. Yang Y, Chen SX, Zhang WX. Effect of ischemic preconditioning on human lung cell apoptosis in vivo and the expression of regulating gene Bcl-2. Hunan Yi Ke Da Xue Xue Bao. 2002;27(1):43–45
  6. Cernak I, Chapman SM, Hamlin GP, Vink R. Temporal characterization of pro- and antiapoptotic mechanisms following diffuse traumatic brain injury in rats. J Clin Neurosci. 2002;9(5):565–572
  7. Fisher AJ, Donnelly SC, Pritchard G, Dark JH, Corris PA. Objective assessment of criteria for selection of donor lungs suitable for transplantation. Thorax. 2004;59(5):434–437
  8. Mathew T. The Australian experience in organ donation–2003. Ann Transplant. 2004;9(1):28–30
  9. Hicsonmez G. The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis. Leuk Res 2005 Jun 23; Epub ahead of print.
  10. Xia F, Cao JS, Zhan LY, Xia ZY, Huang HB. Effect of methylprednisolone on reperfusion injury in severe uncontrolled hemorrhagic shock. Chin J Traumatol. 2003;6(6):359–362
  11. Edmonds HL, Cannon HC, Garretson HD, Dahlquist G. Effects of aerosolized methylprednisolone on experimental neurogenic pulmonary injury. Neurosurgery. 1986;19(1):36–40
  12. Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA. 1911;57:878–880
  13. Yamada Y, Watanabe Y, Zhang J, Haraoka J, Ito H. Changes in cortical and cerebellar Bcl-2 mRNA levels in the developing hydrocephalic Rat (LEW-HYR) as measured by a real time quantified RT-PCR. Neuroscience. 2002;114:165–171
  14. Peirson SN, Butler JN, Foster RG. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res. 2003;31(14):73
  15. Kalinina O, Lebedeva I, Brown J, Silver J. Nanoliter scale PCR with TaqMan detection. Nucleic Acids Res. 1997;25:1999–2004
  16. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45
  17. Mihara M, Uchiyama M. Evaluation of thiobarbituric acid (TBA) value as an index of lipid peroxidation in CCl4-intoxicated rat liver (author's transl). Yakugaku Zasshi. 1981;101(3):221–226
  18. Natale JE, Ahmed F, Cernak I, Stoica B, Faden AI. Gene expression profile changes are commonly modulated across models and species after traumatic brain injury. J Neurotrauma. 2003;20(10):907–927
  19. Gamberoni C, Colombo G, Aspesi M, Mascheroni C, Severgnini P, Minora G, et al. Respiratory mechanics in brain injured patients. Minerva Anestesiol. 2002;68(4):291–296
  20. Mantell LL, Lee PJ. Signal transduction pathways in hyperoxia-induced lung cell death. Mol Genet Metab. 2000;71(1–2):359–370
  21. Budinger GR, Tso M, McClintock DS, Dean DA, Sznajder JI, Chandel NS. Hyperoxia induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins. J Biol Chem. 2002;277(18):15654–15660
  22. Liacos C, Katsaragakis S, Konstadoulakis MM, Messaris EG, Papanicolaou M, Georgiadis GG, et al. Apoptosis in cells of bronchoalveolar lavages: a cellular reaction in patients who die with sepsis and respiratory failure. Crit Care Med. 2001;29(12):2310–2317
  23. Raghupathi R, Graham DI, McIntosh TK. Apoptosis after traumatic brain injury. J Neurotrauma. 2000;17(10):927–938
  24. Yoneda K, Chang MM, Chmiel K, Chen Y, Wu R. Application of high-density DNA micro array to study smoke- and hydrogen peroxide-induced injury and repair in human bronchial epithelial cells. J Am Soc Nephrol. 2003;14(8 Suppl. 3):284–289
  25. Husain KD, Stromberg PE, Javadi P, Buchman TG, Karl IE, Hotchkiss RS, et al. Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Shock. 2003;20(5):437–443
  26. Peralta C, Perales JC, Bartrons R, Mitchell C, Gilgenkrantz H, Xaus C, et al. The combination of ischemic preconditioning and liver Bcl-2 over expression is a suitable strategy to prevent liver and lung damage after hepatic ischemia-reperfusion. Am J Pathol. 2002;160(6):2111–2122
  27. Mouw G, Zechel JL, Zhou Y, Lust WD, Selman WR, Ratcheson RA. Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia. Metab Brain Dis. 2002;17:143–151
  28. Baker AJ. Management of the severely head injured patient. Can J Anaesth. 1999;46(5 Pt 2):35–45
  29. Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D. Antioxidant therapy in acute central nervous system injury: current state. Pharmacol Rev. 2002;54(2):271–284
  30. Alzheimer C, Werner S. Fibroblast growth factors and neuroprotection. Adv Exp Med Biol. 2002;513:335–351
  31. Xiong Y, Lin H, Chen BD, Peterson PL, Lee CP. Appearance of shortened Bcl-2 and Bax proteins and lack of evidence for apoptosis in rat forebrain after severe experimental traumatic brain injury. Biochem Biophys Res Commun 2001 17;286(2):401–5.
  32. Osterreicher J, Kralik M, Navratil L, Vavrova J, Skopek J, Knizek J, et al. Apoptosis and Bcl-2 expression in irradiated lungs and the effect of pentoxyfilline. Acta Medica (Hradec Kralove). 2001;44(4):125–130
  33. Yerramasetti R, Gollapudi S, Gupta S. Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002;22(1):37–47
  34. Yang JT, Lee TH, Weng HH, Chang CN, Chen WC, Wu JH. Dexamethasone enhances NT-3 expression in rat hippocampus after traumatic brain injury. Exp Neurol. 2005;192(2):437–443
  35. Macleod MR, Johansson IM, Soderstrom I, Lai M, Gido G, Wieloch T, et al. Mineralocorticoid receptor expression and increased survival following neuronal injury. Eur J Neurosci. 2003;17(8):1549–1555
  36. McCullers DL, Sullivan PG, Scheff SW, Herman JP. Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat. Neuroscience. 2002;109(2):219–230
  37. Gunnarsson T, Fehlings MG. Acute neurosurgical management of traumatic brain injury and spinal cord injury. Curr Opin Neurol. 2003;16(6):717–723
  38. Zipp F, Wendling U, Beyer M, Grieger U, Waiczies S, Wagenknecht B, et al. Dual effect of glucocorticoids on apoptosis of human auto reactive and foreign antigen-specific T cells. J Neuroimmunol. 2000;110(1–2):214–222
  39. Uckan D, Yetgin S, Cetin M, Ozyurek E, Okur H, Aslan D, et al. The effects of high dose methylprednisolone on apoptosis in children with acute lymphoblastic leukaemia. Clin Lab Haematol. 2003;25(1):35–40

PII: S1443-9506(05)00207-6

doi: 10.1016/j.hlc.2005.10.001

Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 124-129 , April 2006

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