Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 119-123 , April 2006

Fructose 1,6-Diphosphate Administration Attenuates Post-Ischemic Ventricular Dysfunction

  • Jeffrey E. Cohen, BA

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Pavan Atluri, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Matthew D. Taylor, BS

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Todd J. Grand, BS

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • George P. Liao, BS

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Corinna M. Panlilio, BA

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Erik E. Suarez, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Suzanne E. Zentko, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Vivian M. Hsu, BA

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Mark F. Berry, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Maximillian J. Smith

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • Timothy J. Gardner, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • ,
  • H. Lee Sweeney, PhD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Physiology, Philadelphia, PA, United States
    • ,
  • Y. Joseph Woo, MD

      Affiliations

    • University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA, United States
    • Corresponding Author InformationCorresponding author. Division of Cardiothoracic Surgery, 3400 Spruce Street, 6 Silverstein, Philadelphia, PA 19104, United States. Tel.: +1 215 662 2956; fax: +1 215 349 5798.

References 

  1. Markov AK, Brumley MA, Figueroa A, Skelton TN, Lehan PH. Hemodynamic effects of fructose 1,6-diphosphate in patients with normal and impaired left ventricular function. Am Heart J. 1997;133:541–549
  2. Farias LA, Willis M, Gregory GA. Effects of fructose 1,6-diphosphate, glucose, and saline on cardiac resuscitation. Anesthesiology. 1986;65:595–601
  3. Finder DR, Hardin CD. Transport and metabolism of exogenous fumarate and 3-phosphoglycerate in vascular smooth muscle. Mol Cell Biochem. 1999;195:113–121
  4. Hardin CD, Roberts TM. Metabolism of exogenously applied fructose 1,6-bisphosphate in hypoxic vascular smooth muscle. Am J Physiol. 1994;267:H2325–H2332
  5. Starnes JW, Seiler KS, Bowles DK, Giardina B, Lazzarino G. Fructose-1,6-bisphosphate improves efficiency of work in isolated perfused rat hearts. Am J Physiol. 1992;262:H380–H384
  6. Tavazzi B, Starnes JW, Lazzarino G, Di Pierro D, Nuutinen EM, Giardina B. Exogenous fructose 1,6-bisphosphate is a metabolizable substrate for the isolated normoxic rat heart. Basic Res Cardiol. 1992;87:280–289
  7. Zhonglin L, Kastis GA, Stevenson GD, Barrett HH, Furenlid LR, Kupinski MA, et al. Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system. J Nucl Med. 2002;43:933–939
  8. Glitsch HG. Inhibition of the Na pump—a mechanism in the genesis of cardiac arrhythmias. Basic Res Cardiol. 1984;79(6):611–619
  9. Schwartz SM, Duffy JY, Pearl JM, Nelson DP. Cellular and molecular aspects of myocardial dysfunction. Crit Care Med. 2001;29(Suppl.):S214–S219
  10. Kermode H, Chan WM, Williams AJ, Sitsapesan R. Glycolytic pathway intermediates activate cardiac ryanodine receptors. FEBS Lett. 1998;431:59–62
  11. Didlake R, Kirchner KA, Lewin J, Bower JD, Markov AK. Attenuation of ischemic renal injury with fructose 1,6-diphosphate. J Surg Res. 1989;47(3):220–226
  12. Akimitsu T, White JA, Carden DL, Gute DC, Korthuis RJ. Fructose 1,6-diphosphate or adenosine attenuate leukocyte adherence in postischemic skeletal muscle. Am J Physiol. 1995;269(Heart Circ Physiol 38):H1743–H1751
  13. Genesca M, Sola A, Azuara D, De Oca J, Hotter G. Apoptosis inhibition during preservation by fructose-1,6-diphosphate and theophylline in rat intestinal transplantation. Crit Care Med. 2005;33(4):827–834
  14. Taylor MD, Grand TJ, Cohen JE, Hsu V, Liao GP, Zentko S, et al. Ethyl pyruvate enhances ATP levels, reduces oxidative stress, and preserves cardiac function in a rat model of off-pump coronary bypass. Heart Lung Circ. 2005;14:25–31

PII: S1443-9506(05)00281-7

doi: 10.1016/j.hlc.2005.12.004

Heart, Lung and Circulation
Volume 15, Issue 2 , Pages 119-123 , April 2006

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