Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 269-271, August 2006

Left Ventricular Non-Compaction Associated with a Genetic Variant of the CYP2C9 Gene

  • Thomas Bohrer, MD, MA

      Affiliations

    • Department of Cardiothoracic Surgery, Julius-Maximilians University of Wuerzburg, Oberduerrbacherstr. 7, 97080 Wuerzburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 931 201 33001; fax: +49 931 201 33009.
    • ,
  • Hanns-Georg Klein, MD

      Affiliations

    • Center of Human Genetics and Laboratory Medicine, Lochhamer Str. 29, 82152 Martinsried, Germany
    • ,
  • Olaf Elert, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Julius-Maximilians University of Wuerzburg, Oberduerrbacherstr. 7, 97080 Wuerzburg, Germany

Received 12 June 2005; received in revised form 21 February 2006; accepted 22 February 2006.

Polymorphisms in the CYP2C9 gene can have a significant impact on drug therapy by affecting the pharmacokinetics of frequently prescribed drugs, such as phenprocoumon and warfarin. It is essential therefore that genetic CYP2C9 variants are excluded in patients with a suspected intolerance of anticoagulant therapy. Here we present the first report of a case of left ventricular non-compaction syndrome associated with a genetic variant of the CYP2C9 gene in a 45-year-old woman with myocardial insufficiency who was scheduled for implantation of a cardioverter defibrillator.

Keywords: Left ventricular non-compaction, CYP2C9 genotype

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PII: S1443-9506(06)00043-6

doi:10.1016/j.hlc.2006.02.007

Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 269-271, August 2006

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