Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 269-271 , August 2006

Left Ventricular Non-Compaction Associated with a Genetic Variant of the CYP2C9 Gene

  • Thomas Bohrer, MD, MA

      Affiliations

    • Department of Cardiothoracic Surgery, Julius-Maximilians University of Wuerzburg, Oberduerrbacherstr. 7, 97080 Wuerzburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 931 201 33001; fax: +49 931 201 33009.
    • ,
  • Hanns-Georg Klein, MD

      Affiliations

    • Center of Human Genetics and Laboratory Medicine, Lochhamer Str. 29, 82152 Martinsried, Germany
    • ,
  • Olaf Elert, MD, PhD

      Affiliations

    • Department of Cardiothoracic Surgery, Julius-Maximilians University of Wuerzburg, Oberduerrbacherstr. 7, 97080 Wuerzburg, Germany

Received 12 June 2005 ,Revised 21 February 2006 ,Accepted 22 February 2006.

References 

  1. Borges AC, Kivelitz D, Baumann G. Isolated left ventricular noncompaction. Cardiomyopathy with homogeneous transmural and heterogeneous segmental perfusion. Heart. 2003;89:e21
  2. Ritter M, Oechslin E, Sutsch G, et al. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc. 1997;72:26–31
  3. Rendic S, Di Carlo F. Human cytochrome P450 enzymes: a status report summarizes their reactions, substrates, inducers and inhibitors. Drug Metab Rev. 1997;29:413–580
  4. He M, Korzekwa KR, Jones JP, et al. Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9. Arch Biochem Biophys. 1999;372:16–28
  5. Aithal GP, Day CP, Kevesten PJL, et al. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999;353:688–689717–9
  6. Yasar Ü, Eliasson E, Dahl ML, et al. Validation of methods for CYP2C9 genotyping: frequencies of mutant allels in a Swedish population. Biochem Biophys Res Commun. 1999;254:628–631
  7. Ogg MS, Brennan P, Meade T, et al. CYP2C9*3 allelic variant and bleeding complications. Lancet. 1999;354:1124
  8. Oechslin EN, Attenhofer Jost CH, Rojas JR, et al. Long-term follow-up of 34 adults with left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000;36:493–500
  9. Barth PG, Valianpour F, Bowen VM, et al. X-linked cardioskeletal myopathy and neutropenia (Barth syndrome): An update. Am J Med Gen. 2004;126A:349–354
  10. Weiford BC, Subbarao VD, Mulhern KM. Noncompaction of the ventricular myocardium. Circulation. 2004;109:2965–2971
  11. Ichida F, Tsubata T, Bowles KR, et al. Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation. 2001;103:1256–1263

PII: S1443-9506(06)00043-6

doi: 10.1016/j.hlc.2006.02.007

Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 269-271 , August 2006

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