Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 261-265 , August 2006

Evaluation of Epsilon Amino-Caproic Acid (EACA) and Autologous Blood as Blood Conservation Strategies in Patients Undergoing Cardiac Surgery

Received 22 March 2006 ,Revised 29 March 2006 ,Accepted 31 March 2006.

References 

  1. Havel M, Teufelsbauer H, Knobl P. The effect of intra-operative aprotinin administration on post-operative bleeding in patients undergoing cardiopulmonary bypass surgery. J Thorac Cardiovasc Surg. 1991;101:968–972
  2. Knobl PN, Zilla P, Fasol R. The protein C system in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1987;94:600–605
  3. Hiratzka LH, Richardson JV, Brandt B. The effect of autologous blood salvage techniques upon bank blood usage and cost of routine coronary revascularization. Perfusion. 1986;1:239–244
  4. Hoffman EP, Koo AH. Cerebral thrombosis associated with Amicar. Radiology. 1979;131:687–689
  5. Naeye L. Thrombotic state after hemorrhagic diathesis, a possible complication of therapy with E-aminocaproic acid. Blood. 1962;19:694–701
  6. Rydin E, Lundberg PO. Tranexamic acid and intracranial thrombosis. Lancet. 1976;2:49–51
  7. Sonntang VKH, Stein BM. Arteriopathic complications during treatment of sub-arachnoid haemorrhage with E-aminocaproic acid. J Neurosurg. 1974;40:480–485
  8. Kaplan JA, Cannarella C, Jones EL. Autologous blood transfusion during cardiac surgery. A re-evaluation of three methods. J Thorac Cardiovasc Surg. 1977;74:4–10
  9. Tempe D, Bajwa R, Cooper A, Nag B, Tomar AS, Khanna SK, et al. Blood conservation in small adults undergoing valve surgery. J Cardiothorac Vasc Anesth. 1996;10:502–506
  10. Diprose P, Herberston MJ, O'Shaughnessy D, Deakin CD, Gill RS. Reducing allogenic transfusion in cardiac surgery:a randomized double-blind placebo-controlled trial of antifibrinolytic therapies used in addition to intra-operative cell salvage. Br J Anaesth. 2005;94:271–278
  11. Penta de Peppo A, Pierri MD, Scafuri A, De Paulis R, Coluntuono G, Capara E, et al. Intra-operative antifibrinolysis and blood-saving techniques in cardiac surgery. Prospective trial of 3 antifibrinolytic drugs. Tex Heart Inst J. 1995;22:231–236
  12. Levi M, Cromheecke ME, de Jonge E, Prins MH, de Mol BJ, Briet E, et al. Pharmacological strategies to decrease exsceesive blood loss in cardiac surgery: a meta-analysis of clinically relevant end points. Lancet. 1999;354:1940–1947
  13. Liu YC, Tsai TP. The effect of coagulation protection with combination of epsilon amino-caproic acid and plasma saver in open-heart surgery. Acta Anaesthesiol Scan. 1998;36:149–154
  14. Kochamba GS, Pfeffer TA, Sintek CF, Khonsari S. Intra-operative autotransfusion reduces blood loss after cardiopulmonary bypass. Ann Thorac Surg. 1996;61:900–903

PII: S1443-9506(06)00083-7

doi: 10.1016/j.hlc.2006.03.014

Heart, Lung and Circulation
Volume 15, Issue 4 , Pages 261-265 , August 2006