Heart, Lung and Circulation
Volume 15, Issue 5 , Pages 325-331 , October 2006

“Initial, Continuous and Intermittent Bolus” Administration of Minimally-Diluted Blood Cardioplegia Supplemented with Potassium and Magnesium for Hypertrophied Hearts

Received 25 March 2006 ,Revised 13 May 2006 ,Accepted 9 June 2006.

References 

  1. Zhu Y-C, Zu Y-Z, Spitznagel H, Gohlke P, Unger T. Substrate metabolism, hormone interaction, and angiotensin-converting enzyme inhibitors in left ventricular hypertrophy. Diabetes. 1996;45:S59–S65
  2. Suleiman M-S, Caputo M, Ascione R, Bryan AJ, Lucchetti V, Gomes WJ, et al. Metabolic differences between hearts of patients with aortic disease and hearts of patients with ischeamic disease. J Mol Cell Cardiol. 1998;30(suppl. 1):2519–2523
  3. Gundry SR, Wang N, Bannon D, Vigesaa RE, Eke C, Pain S, et al. Retrograde continuous warm blood cardioplegia: maintenance of myocardial homeostasis in humans. Ann Thorac Surg. 1993;55:358–363
  4. Anderson WA, Berrizbeitia LD, Ilkowski DA, Cha R, Gu J, Fernandez J, et al. Normothermic retrograde cardioplegia is effective in patients with left ventricular hypertrophy—a prospective randomized study. J Cardiovasc Surg. 1995;36:17–24
  5. Torracca L, Pasini E, Curello S, Ceconi C, Coletti G, Alfieri O, et al. Continuous versus intermittent warm blood cardioplegia: functional and energetics changes. Ann Thorac Surg. 1996;62:1172–1179
  6. Weng ZC, Nicolosi AC, Detwiler PW, Hsu DT, Schierman SW, Goldstein AH, et al. Effects of crystalloid, blood, and University of Wisconsin perfusates on weight, water content, and left ventricular compliance in an edema-prone, isolated porcine heart model. J Thorac Cardiovasc Surg. 1992;103:504–513
  7. Mehlhorn U, Allen SJ, Davis KL, Geissler HJ, Warters RD, Rainer de Vivie E. Increasing the colloid osmotic pressure of cardiopulmonary bypass prime and normothermic blood cardioplegia minimizes myocardial oedema and prevents cardiac dysfunction. Cardiovasc Surg. 1998;6:274–281
  8. Hayashi Y, Ohtani M, Sawa Y, Hiraishi T, Akedo H, Kobayashi Y, et al. Minimally-diluted blood cardioplegia supplemented with potassium and magnesium for combination of ‘initial, continuous and intermittent bolus’ administration. Circ J. 2004;68:467–472
  9. Schroeder E, Marchandise B, Schoevaerdts JC, Kremer R. Paradoxical ventricular septal motion after cardiac surgery. Analysis of M-mode echocardiograms and follow-up in 324 patients. Acta Cardiol. 1985;40:315–324
  10. Feneley M, Kearney L, Farnsworth A, Shanahan M, Chang V. Mechanisms of the development and resolution of paradoxical interventricular septal motion after uncomplicated cardiac surgery. Am Heart J. 1987;114(1 Pt 1):106–114
  11. Landymore RW, Marble AE. Effect of hypothermia and cardioplegia on intra-myocardial voltage and myocardial oxygen consumption. Can J Surg. 1990;33:45–48
  12. Landymore RW, Marble AE, Eng P, MacAulay MA, Fris J. Myocardial oxygen consumption and lactate production during antegrade warm blood cardioplegia. Eur J Cardiothorac Surg. 1992;6:372–376
  13. Buckberg GD. Update on current techniques of myocardial protection. Ann Thorac Surg. 1995;60:805–814
  14. Mauney MC, Kron IL. The physiologic basis of warm cardioplegia. Ann Thorac Surg. 1995;60:819–823
  15. Landymore RW, Marble AE, Fris J. Effect of intermittent delivery of warm blood cardioplegia on myocardial recovery. Ann Thorac Surg. 1994;57:1267–1272
  16. Le Deist F, Menasche P, Kucharski C, Bel A, Piwnica A, Bloch G. Hypothermia during cardiopulmonary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Circulation. 1995;92(9 Suppl.):II354–II358
  17. Honore PM, Jacquet LM, Beale RJ, Renauld JC, Valadi D, Noirhomme P, et al. Effects of normothermia versus hypothermia on extravascular lung water and serum cytokines during cardiopulmonary bypass: a randomized, controlled trial. Crit Care Med. 2001;29:1903–1909
  18. Lewis ME, Al-Khalidi AH, Townend JN, Coote J, Bonser RS. The effects of hypothermia on human left ventricular contractile function during cardiac surgery. J Am Coll Cardiol. 2002;39:102–108
  19. Calafiore AM, Teodori G, Mezzetti A, Bosco G, Verna AM, DiGiammarco G, et al. Intermittent antegrade warm blood cardioplegia. Ann Thorac Surg. 1995;59:398–402
  20. Hayashida N, Isomura T, Sato T, Maruyama H, Higashi T, ArinagaK , et al. Minimally diluted tepid blood cardioplegia. Ann Thorac Surg. 1998;65:615–621
  21. Allen BS, Winkelmann JW, Hanafy H, Hartz RS, Bolling KS, Ham J, et al. Retrograde cardioplegia does not adequately perfuse the right ventricle. J Thorac Cardiovasc Surg. 1995;109:1116–1126
  22. Gates RN, Lee J, Laks H, Drinkwater DC, Rhudis E, Aharon AS, et al. Evidence of improved microvascular perfusion when using antegrade and retrograde cardioplegia. Ann Thorac Surg. 1996;62:1388–1391
  23. Melrose DG, Dreyer B, Bentall HH, Baker JB. Elective cardiac arrest. Lancet. 1955;269:21–22
  24. Ataka K, Chen D, McCully J, Levitsky S, Feinberg H. Magnesium cardioplegia prevents accumulation of cytosolic calcium in the ischemic myocardium. J Mol Cell Cardiol. 1993;25:1387–1390
  25. Caputo M, Bryan AJ, Calafiore AM, Suleiman MS, Angelini GD. Intermittent antegrade hyperkalaemic warm blood caridoplegia supplemented with magnesium prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery. Eur J Cardiothorac Surg. 1998;14:596–601
  26. Miyoshi K, Taniguchi M, Seki S, Mochizuki S. Effects of magnesium and its mechanism on the incidence of reperfusion arrhythmias following severe ischemia in isolated rat hearts. Cardiovasc Drugs Ther. 2000;14:625–633
  27. Yeatman M, Caputo M, Narayan P, Lotto AA, Ascione R, Bryan AJ, et al. Magnesium-supplemented warm blood cardioplegia in patients undergoing coronary artery revascularization. Ann Thorac Surg. 2002;73:112–118
  28. Matsuda H, Maeda S, Hirose H, Nakano S, Shirakura R, Kaneko M, et al. Optimum dose of cold potassium cardioplegia for patients with chronic aortic valve disease: determination by left ventricular mass. Ann Thorac Surg. 1986;41:22–26
  29. Sawa Y, Taniguchi K, Kadoba K, Nishimura M, Ichikawa H, Amemiya A, et al. Leukocyte depletion attenuates reperfusion injury in patients with left ventricular hypertrophy. Circulation. 1996;93:1640–1646

 Part of this study was presented at the 51st Annual Conference of American Society for Internal Artificial Organs, held in Washington DC, USA (June 9–11, 2005).

PII: S1443-9506(06)00130-2

doi: 10.1016/j.hlc.2006.06.004

Heart, Lung and Circulation
Volume 15, Issue 5 , Pages 325-331 , October 2006