Heart, Lung and Circulation
Volume 17, Issue 5 , Pages 411-413 , October 2008

Detection of Familial Hypercholesterolaemia: A Major Treatment Gap in Preventative Cardiology

  • Timothy R. Bates, FRACP

      Affiliations

    • Lipid Disorders Clinic and Department of Internal Medicine, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • ,
  • John R. Burnett, MD, PhD

      Affiliations

    • Lipid Disorders Clinic and Department of Internal Medicine, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine WA, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • School of Surgery and Pathology, University of Western Australia, MRF Building, 50 Murray Street, Level 4, Perth, Western Australia 6000, Australia
    • ,
  • Frank M. van Bockxmeer, PhD, FAHA

      Affiliations

    • School of Surgery and Pathology, University of Western Australia, MRF Building, 50 Murray Street, Level 4, Perth, Western Australia 6000, Australia
    • Cardiovascular Genetics Laboratory, Division of Laboratory Medicine, PathWest Laboratory Medicine WA, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • ,
  • Sandra Hamilton, BSc

      Affiliations

    • Lipid Disorders Clinic and Department of Internal Medicine, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • School of Medicine and Pharmacology, University of Western Australia, MRF Building, 50 Murray Street, Level 4, Perth, Western Australia 6000, Australia
    • ,
  • Leonard Arnolda, PhD, FRACP

      Affiliations

    • School of Medicine and Pharmacology, University of Western Australia, MRF Building, 50 Murray Street, Level 4, Perth, Western Australia 6000, Australia
    • Department of Cardiology, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • ,
  • Gerald F. Watts, DSc, FRACP

      Affiliations

    • Lipid Disorders Clinic and Department of Internal Medicine, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    • School of Medicine and Pharmacology, University of Western Australia, MRF Building, 50 Murray Street, Level 4, Perth, Western Australia 6000, Australia
    • Corresponding Author InformationCorresponding author at: Lipid Disorders Clinic, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia. Tel.: +61 8 9224 0245; fax: +61 8 9224 0246.

Received 26 March 2007 ,Revised 12 May 2007 ,Accepted 6 June 2007.

References 

  1. Marks D, Thorogood M, Neil A, Humphries S. A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis. 2003;168:1–14
  2. Neil H, Hammond T, Huxley R, Matthews D, Humphries S. Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study. BMJ. 2000;321:148
  3. Eurospire II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries. Principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J. 2001;22:554–572
  4. Vale M, Jelinek M, Best J for the COACH study group. How many patients with coronary heart disease are not achieving their risk-factor targets? Experience in Victoria 1996–1998 versus 1999–2000. Med J Aust. 2002;176:211–215
  5. Dorsch M, Lawrance R, Durham N, Hall A. Familial hypercholesterolaemia is underdiagnosed after AMI. BMJ. 2001;322:111
  6. Hamilton-Craig I. Case-finding for familial hypercholesterolemia in the Asia-Pacific region. Semin Vasc Med. 2004;4:87–92
  7. Marks D, Wonderling D, Thorogood M, Lambert H, Humphries S. Cost effectiveness analysis of different approaches of screening for familial hypercholesterolaemia. BMJ. 2002;324:1–6

PII: S1443-9506(07)00273-9

doi: 10.1016/j.hlc.2007.06.005

Heart, Lung and Circulation
Volume 17, Issue 5 , Pages 411-413 , October 2008

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