Heart, Lung and Circulation
Volume 16, Issue 5 , Pages 356-360 , October 2007

Atrial Fibrillation—A New Cardiac Channelopathy

  • Robyn Otway, PhD

      Affiliations

    • Sr Bernice Research Program in Inherited Heart Diseases, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010 Australia
    • ,
  • Jamie I. Vandenberg, MBBS, PhD

      Affiliations

    • Mark Cowley Lidwill Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia
    • Faculties of Medicine and Life Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    • ,
  • Diane Fatkin, MD

      Affiliations

    • Sr Bernice Research Program in Inherited Heart Diseases, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010 Australia
    • Faculties of Medicine and Life Sciences, University of New South Wales, Kensington, NSW 2052, Australia
    • Cardiology Department, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia
    • Corresponding Author InformationCorresponding author at: Victor Chang Cardiac Research Institute, Level 6, 384 Victoria Street, Darlinghurst, NSW 2010 Australia. Tel.: +61 2 9295 8518; fax: +61 2 9295 8501.

References 

  1. Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, et al. Lifetime risk for development of atrial fibrillation. Circulation. 2004;110:1042–1046
  2. Miyasaka Y, Barnes ME, Gersh BJ, Cha SS, Bailey KR, Abhayaratna WP, et al. Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence. Circulation. 2006;114:119–125
  3. Thomas SP. Operative and percutaneous procedures for cure of atrial fibrillation.. Heart Lung Circ. 2007;16:229–233
  4. Ashcroft FM. From molecule to malady. Nature. 2006;440:440–447
  5. Nerbonne JM, Kass RS. Molecular physiology of cardiac repolarization. Physiol Rev. 2005;85:1205–1253
  6. Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, et al. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol. 2007;582:675–693
  7. McNair WP, Ku L, Taylor MRG, Fain PR, Dao D, Wolfel E, et al. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation. 2004;110:2163–2167
  8. Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, et al. Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA. 2005;293:447–454
  9. Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O’Cochlain F, Gao F, et al. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 2004;36:382–387
  10. Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell. 2001;104:569–580
  11. George AL. Inherited disorders of voltage-gated sodium channels. J Clin Invest. 2005;115:1990–1999
  12. Orgain ES, Wolff L, White PD. Uncomplicated auricular fibrillation and flutter: frequent occurrence and good prognosis in patients without other evidence of cardiac disease. Arch Int Med. 1936;57:493–513
  13. Darbar D, Herron KJ, Ballew JD, Jahangir A, Gersh BJ, Shen WK, et al. Familial atrial fibrillation is a genetically heterogeneous disorder. J Am Coll Cardiol. 2003;41:2185–2192
  14. Ellinor PT, Yoerger DM, Ruskin JN, MacRae CA. Familial aggregation in lone atrial fibrillation. Hum Genet. 2005;118:179–184
  15. Fox CS, Parise H, D’Agostino RB, Lloyd-Jones DM, Vasan RS, Wang TJ, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291:2851–2855
  16. Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006;27:708–712
  17. Brugada R, Tapscott T, Czernuszewicz GZ, Marian AJ, Iglesias A, Mont L, et al. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997;336:905–911
  18. Ellinor PT, Shin JT, Moore RK, Yoerger DM, MacRae CA. Locus for atrial fibrillation maps to chromosome 6q14–16. Circulation. 2003;107:2880–2883
  19. Volders PG, Zhu Q, Timmermans C, Eurlings PM, Su X, Arens YH, et al. Mapping a novel locus for familial atrial fibrillation on chromosome 10p11–q21. Heart Rhythm. 2007;4:469–475
  20. Oberti C, Wang L, Li L, Dong J, Rao S, Du W, et al. Genome-wide linkage scan identifies a novel genetic locus on chromosome 5p13 for neonatal atrial fibrillation associated with sudden death and variable cardiomyopathy. Circulation. 2004;110:3753–3759
  21. Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003;299:251–254
  22. Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, et al. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004;75:899–905
  23. Xia M, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, et al. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun. 2005;332:1012–1019
  24. Nattel S. New ideas about atrial fibrillation 50 years on. Nature. 2002;415:219–226
  25. Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1. 5 cloned currents. Circ Res. 1993;73:1061–1076
  26. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res. 1997;80:772–781
  27. Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet. 2006;15:2185–2191
  28. Olson TM, Alekseev AE, Moreau C, Liu XK, Zingman LV, Miki T, et al. KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. Nat Clin Pract. 2007;4:110–116
  29. Ellinor PT, Moore RK, Patton KK, Ruskin JN, Pollak MR, MacRae CA. Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation. Heart. 2004;90:1487–1488
  30. Ellinor PT, Petrov-Kondratov VI, Zakharova E, Nam EG, MacRae CA. Potassium channel gene mutations rarely cause atrial fibrillation. BMC Med Genet. 2006;7:70
  31. Otway R, Vandenberg JI, Guo G, Varghese A, Castro ML, Liu J, et al. Stretch-sensitive KCNQ1 mutation: a link between genetic and environmental factors in the pathogenesis of atrial fibrillation?. J Am Coll Cardiol. 2007;49:578–586
  32. Fatkin D, Otway R, Vandenberg JI. Genes and atrial fibrillation: a new look at an old problem. Circulation. 2007;116:782–792
  33. Nattel S, Maguy A, Le Bouter S, Yeh Y-H. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007;87:425–456
  34. Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, et al. Reprogramming of the human atrial transcriptome in permanent atrial fibrillation. Expression of a ventricular-like genomic signature. Circ Res. 2005;96:1022–1029
  35. Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, et al. Human atrial ion channel and transporter subunit gene-expression remodelling associated with valvular heart disease and atrial fibrillation. Circulation. 2005;112:471–481

PII: S1443-9506(07)00847-5

doi: 10.1016/j.hlc.2007.07.003

Heart, Lung and Circulation
Volume 16, Issue 5 , Pages 356-360 , October 2007

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