Heart, Lung and Circulation
Volume 16, Issue 5 , Pages 331-334 , October 2007

Pacemaker Cell and Atrial Function: Unravelling How Calcium Initiates and Regulates the Heart Beat and How Ionic Dysfunction, ‘Channelopathies’ and Other Membrane Remodelling Contribute to Atrial Fibrillation

  • Salvatore Pepe, PhD, FAHA, FCSANZ

      Affiliations

    • Laboratory of Cardiothoracic Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Australia
    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Australia
    • Corresponding Author InformationCorresponding author at: Department of Cardiothoracic Surgery 3F, Alfred Hospital, P.O. Box 315, Prahran, VIC 3181, Australia.
    • ,
  • Lea M.D. Delbridge, PhD

      Affiliations

    • Laboratory of Cardiothoracic Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Australia
    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Australia

References 

  1. Maltsev VA, Lakatta EG. Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells. Heart Lung and Circulation. 2007;16:335–348
  2. Ju Y-K, Allen DG. Store-operated Ca2+ entry and TRPC expression; possible roles in Cardiac Pacemaker tissue. Heart Lung and Circulation. 2007;16:349–355
  3. Kelly D, Mackenzie L, Hunter P, Smaill B, Saint DA. Gene expression of stretch-activated channels and mechanoelectric feedback in the heart. Clin Exp Pharmacol Physiol. 2006;33:642–648
  4. Steinberg JS, Sadaniantz A, Kron J, Krahn A, Denny DM, Daubert J, et al. Analysis of cause-specific mortality in the atrial fibrillation follow-up investigation of rhythm management (AFFIRM) study. Circulation. 2004;109(7):1973–1980
  5. Murphy GJ, Ascione R, Caputo M, Angelini GD. Operative factors that contribute to post-operative atrial fibrillation: a prospective randomized trial. J Thorac Cardiovasc Surg. 2003;126:2058–2064
  6. Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen MS. OPTIMAAL investigators. Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by LV dysfunction: OPTIMAAL experience. Eur Heart J. 2005;26:350–356
  7. Mihm MJ, Yu F, Carnes CA, Reiser PJ, McCarthy PM, Bauer JA. Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001;104:174–180
  8. Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation. 1997;96:1180–1184
  9. Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res. 2002;54:230–246
  10. Schotten U, Greiser M, Benke D, Buerkel K, Ehrenteidt B, Stellbrink C, et al. Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort. Cardiovasc Res. 2002;53:192–201
  11. Van Wagoner DR. Electrophysiological remodeling in human atrial fibrillation. Pacing Clin Electrophysiol. 2003;26(7 Pt 2):1572–1575
  12. Kistler PM, Sanders P, Fynn SP, Stevenson IH, Spence SJ, Vohra JK, et al. Electrophysiologic and electroanatomic changes in the human atrium associated with age. J Am Coll Cardiol. 2004;44:109–116
  13. Conway DS, Buggins P, Hughes E, Lip GY. Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillation. Am Heart J. 2004;148:462–466
  14. Anderson JL, Allen Maycock CA, Lappé DL, Crandall BG, Horne BD, Bair TL, et al. Frequency of elevation of C-reactive protein in atrial fibrillation. Am J Cardiol. 2004;94:1255–1259
  15. Falk RH. Atrial fibrillation. N Engl J Med. 2001;344:1067–1068
  16. Gaudino M, Andreotti F, Zamparelli R, Di Castelnuovo A, Nasso G, Burzotta F, et al. The -174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation. Is atrial fibrillation an inflammatory complication?. Circulation. 2003;108(Suppl. 1):II195–II199
  17. Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460–2466
  18. Burzotta F, Iacoviello L, Di Castelnuovo A, Glieca F, Luciani N, Zamparelli R, et al. Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization. Am J Cardiol. 2001;88:1125–1128
  19. Pepe S. Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes. Exp Gerontol. 2005;40:751–758
  20. Pepe S. Dietary polyunsaturated fatty acids and age-related membrane changes in the heart. Ann N Y Acad Sci 2007 [in press].
  21. Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, et al. Fish intake and risk of incident atrial fibrillation. Circulation. 2004;110:368–373
  22. Calo L, Bianconi L, Colivicchi F, Lamberti F, Loricchio ML, de Ruvo E, et al. N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol. 2005;45:1723–1728
  23. Otway R, Vandenberg JI, Fatkin D. Atrial fibrillation—a new cardiac channelopathy. Heart Lung and Circulation. 2007;16:356–360
  24. Fox CS, Parise H, D’Agostino RB, Lloyd-Jones DM, Vasan RS, Wang TJ, et al. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004;291:2851–2855
  25. Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006;27:708–712
  26. Hool L. What cardiologists should know about calcium ion channels and their regulation by reactive oxygen species. Heart Lung and Circulation. 2007;16:361–372

PII: S1443-9506(07)00872-4

doi: 10.1016/j.hlc.2007.09.002

Heart, Lung and Circulation
Volume 16, Issue 5 , Pages 331-334 , October 2007

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