Domiciliary Oxygen Therapy Improves Sub-Maximal Exercise Capacity and Quality of Life in Chronic Heart Failure

Introduction

A high prevalence of nocturnal hypoxia is noted in patients with chronic heart failure (CHF). Nocturnal hypoxia can be reversed by nasal oxygen or non-invasive assisted ventilation. However, controversy exists over the use of oxygen in CHF.

We studied the effects of nocturnal nasal oxygen in CHF to demonstrate its effects on 6-min walk test, quality of life (QOL), NTproBNP, and echocardiographic parameters.

Methodology

Ten patients aged 70±9 years received domiciliary oxygen (4l/min) for one month. Oxygen was administered for a minimum of 8h every night via nasal prongs.

Results

A 17% improvement was seen in the 6-min walk test, 298±98m to 351±100m (p=0.005) and a 27% improvement in the QOL, which improved from 26±12 to 19±7 (p=0.017). Acquired echocardiographic measures including ejection fraction, pulmonary pressure and diastolic parameters did not change.

Conclusion

Nocturnal nasal oxygen has a significant impact on sub-maximal exercise capacity and QOL in CHF. Although a previous study has demonstrated harmful haemodynamic effects of acute oxygen administration in CHF; we did not detect any change in echocardiographic parameters using current two-dimensional imaging and Doppler studies. The lack of improvement in cardiac parameters suggests a peripheral mode of action.

Keywords: Domiciliary, Oxygen, Chronic heart failure, Echocardiogram