Heart, Lung and Circulation
Volume 17, Issue 6 , Pages 451-462, December 2008

Molecular Profiling of Non-Small Cell Lung Cancer: Of What Value in Clinical Practice?

  • Genni M. Newnham, FRACP

      Affiliations

    • Department of Medical Oncology, St Vincent's Hospital, Melbourne, Australia
    • ,
  • David M. Thomas, FRACP

      Affiliations

    • Ian Potter Foundation, Centre for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia
    • ,
  • Sue Anne McLachlan, FRACP

      Affiliations

    • Department of Medical Oncology, St Vincent's Hospital, Melbourne, Australia
    • ,
  • Gavin Wright, FRACS

      Affiliations

    • Cardiothoracic Care Centre, St Vincent's Hospital, Melbourne, Australia
    • Corresponding Author InformationCorresponding author at: East Melbourne Heart & Lung, 55 Victoria Parade, Fitzroy, VIC 3065, Australia. Tel.: +61 3 9415 8329; fax: +61 3 9417 1694.
    • ,
  • Matthew Conron, FRACP

      Affiliations

    • Department of Respiratory Medicine, St Vincent's Hospital, Melbourne, Australia

Received 23 May 2007; accepted 14 November 2007.

Future improvements in lung cancer survival are likely to come from delineating its putative oncogenic pathways. The development of microarray technology to perform thousands of simultaneous genetic experiments and the linking of this to clinical information is an imperative for refining our current treatments and developing new ones. This paper reviews the state of this research, describes a typical microarray experiment and the implications for diagnosis and treatment of non-small cell lung cancer.

Keywords: DNA fingerprinting, Gene expression profiling, Genomics, Medical informatics, Nucleic acid hybridisation, RNA

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PII: S1443-9506(08)00171-6

doi:10.1016/j.hlc.2007.11.144

Heart, Lung and Circulation
Volume 17, Issue 6 , Pages 451-462, December 2008

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