Heart, Lung and Circulation
Volume 17, Issue 6 , Pages 445-450 , December 2008

Benchmarking Ventricular Arrhythmias in the Mouse—Revisiting the ‘Lambeth Conventions’ 20 Years On

  • Catherine E. Huggins, PhD

      Affiliations

    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    • ,
  • James R. Bell, PhD

      Affiliations

    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    • ,
  • Salvatore Pepe, PhD

      Affiliations

    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia
    • Laboratory of Cardiac Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Melbourne, Australia
    • Corresponding Author InformationCorresponding author at: Department of Surgery, Monash University, Alfred Hospital Melbourne, Victoria 3004, Australia. Tel.: +61 3 9903 0813; fax: +61 3 9903 0618.
    • ,
  • Lea M.D. Delbridge, PhD

      Affiliations

    • Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia

Received 7 May 2008 ,Accepted 12 August 2008.

References 

  1. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res. 1988;22:447–455
  2. Skrzypiec-Spring M, Grotthus B, Szelag A, Schulz R. Isolated heart perfusion according to Langendorff—still viable in the new millennium. J Pharmacol Toxicol Methods. 2007;55:113–126
  3. Nilles KM, London B. Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them?. J Cardiovasc Electrophysiol. 2007;18:1117–1125
  4. Curtis MJ, Macleod BA, Walker MJ. Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat. J Mol Cell Cardiol. 1987;19:399–419
  5. Headrick J. Aging impairs functional, metabolic and ionic recovery from ischaemia–reperfusion and hypoxia-reoxygenation. J Mol Cell Cardiol. 1998;30:1415–1430
  6. Huggins CE, Domenighetti AA, Pedrazzini T, Pepe S, Delbridge LMD. Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice. J Renin Angiotensin Aldosterone Syst. 2003;4:186–190
  7. Oudot A, Vergely C, Ecarnot-Laubriet A, Rochette L. Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia–reperfusion. Eur J Pharmacol. 2003;462:145–154
  8. Tokuno S, Jinokiyama K, Tokuno K, Lowbeer C, Hansson LO, Valen G. Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischaemia. Arterioscler Thromb Vasc Biol. 2002;22:995–1001
  9. Tiemann K, Weyer D, Djoufack PC, Ghanem A, Lewalter T, Dreiner U, et al. Increasing myocardial contraction and blood pressure in C57BL/6 mice during early postnatal development. Am J Physiol Heart Circ Physiol. 2003;284:H464–H474
  10. Liu G, Iden JB, Kovithavongs K, Gulamhusein R, Duff HJ, Kavanagh KM. In vivo temporal and spatial distribution of depolarization and repolarization and the illusive (sic) murine T wave. J Physiol. 2004;555(Pt 1):267–279
  11. Domenighetti AA, Boixel C, Cefai D, Abriel H, Pedrazzini T. Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation. J Mol Cell Cardiol. 2007;42:63–70
  12. Langendorf R, Pick A, Winternitz M. Mechanisms of intermittent ventricular bigeminy. I. Appearance of ectopic beats dependent upon length of the ventricular cycle, the “rule of bigeminy”. Circulation. 1955;11:422–430
  13. Pepe S, McLennan PL. Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. J Nutr. 1996;126:34–42
  14. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, et al. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci USA. 2006;103:12179–12184
  15. Ng GA. Treating patients with ventricular ectopic beats. Heart. 2006;92:1707–1712
  16. Clusin WT. Calcium and cardiac arrhythmias: DADs, EADs, and alternans. Crit Rev Clin Lab Sci. 2003;40:337–375
  17. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin Invest. 2005;115:2305–2315
  18. Lerma C, Lee CF, Glass L, Goldberger AL. The rule of bigeminy revisited: analysis in sudden cardiac death syndrome. J Electrocardiol. 2007;40:78–88
  19. Wang K, Asinger RW, Marriott HJ. Bigeminal rhythms, common and uncommon mechanisms. J Electrocardiol. 2001;40:135–138
  20. Mattheussen M, Mubagwa K, Rusy BF, Van Aken H, Flameng W. Potentiated state contractions in isolated hearts: effects of ischaemia and reperfusion. Am J Physiol. 1993;264(5 Pt 2):H1663–H1673
  21. Narayan SM. T-wave alternans and the susceptibility to ventricular arrhythmias. J Am Coll Cardiol. 2006;47:269–281
  22. Orchard CH, McCall E, Kirby MS, Boyett MR. Mechanical alternans during acidosis in ferret heart muscle. Circ Res. 1991;68:69–76
  23. Picht E, DeSantiago J, Blatter LA, Bers DM. Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res. 2006;99:740–748
  24. Bell JR, Porrello ER, Huggins CE, Harrap SB, Delbridge LMD. The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy. Am J Physiol—Heart Circ Physiol. 2008;294(4):H1514–H1522

PII: S1443-9506(08)00858-5

doi: 10.1016/j.hlc.2008.08.006

Heart, Lung and Circulation
Volume 17, Issue 6 , Pages 445-450 , December 2008

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