Heart, Lung and Circulation
Volume 18, Issue 3 , Pages 181-183 , June 2009

NICE Guidance on Familial Hypercholesterolaemia: All Sugar and Spice?

  • Gerald F. Watts, DSc, MD, FRCP, FRACP

      Affiliations

    • School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Level 4, Medical Research Foundation Building, Rear 50 Murray Street, Perth, Western Australia 6000, Australia
    • Corresponding Author InformationCorresponding author at: School of Medicine & Pharmacology, Royal Perth Hospital Unit, GPO Box X2213, WA 6847, Australia. Tel.: +61 8 9224 0248; fax: +61 8 9224 0246.
    • ,
  • Ian Hamilton-Craig, PhD, FRACP, FCSANZ

      Affiliations

    • School of Medicine, Griffith University, Gold Coast, University Drive, Meadowbrook, Queensland 4131, Australia
    • ,
  • David R. Sullivan, FRACP, FRCPA

      Affiliations

    • School of Molecular and Microbial Biosciences, Royal Prince Alfred Hospital, The University of Sydney, Sydney, New South Wales 2006, Australia

Received 11 June 2008

References 

  1. Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholesterolemia: new insights in pathogenesis and treatment. J Clin Invest. 2003;111:1795–1803
  2. Marks D, Thorogood M, Neil HAW, Humphries SE. A review on the diagnosis, natural history, and treatment of familial hypercholesterolemia. Atherosclerosis. 2003;168:1–14
  3. Watts GF, Lewis B, Sullivan DR. Familial hypercholesterolaemia: a missed opportunity in preventive medicine. Nat Clin Pract Cardiovasc Med. 2007;4:404–405
  4. Ceveira F. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis. 2004;173:55–68
  5. Burnett JR, Ravine D, van Bockxmeer FM, Watts GF. Familial hypercholesterolaemia: a look back, a look ahead. MJA. 2005;182(11):552
  6. Bates TR, Burnett JR, van Bockxmeer FM, Hamilton S, Arnolda L, Watts GF. Detection of familial hypercholesterolaemia: a major treatment gap in preventative cardiology. Heart Lung Circ. 2008;17:411–413
  7. Wierzbicki AS, Humphries SE, Minhas R. Familial hypercholesterolaemia:summary of NICE guidance. BMJ. 2008;337:509–510
  8. National Institute for Health and Clinical Excellence. Clinical guidelines and evidence review for familial hypercholesterolaemia: the identification and management of adults and children with familial hypercholesterolaeimia; 2008 (clinical guideline 71), www.nice.org.uk/CG71.
  9. Marks D, Wonderling D, Thorogood M, Lambert H, Humphries SE. Cost-effectiveness of different approaches of screening for familial hypercholesterolaemia. BMJ. 2002;324:1303–1308
  10. Leren TP. Cascade genetic screening for familial hypercholesterolemia. Clin Genet. 2004;66:483–487
  11. World Health Organisation. Familial hypercholesterolemia (FH). Report of a WHO Consultation. Geneva: World Health Organisation, Human Genetics Programme; 1997.
  12. World Health Organization. Familial hypercholesterolaemia. Report of a second WHO Consultation. Geneva: World Health Organization; 1999.
  13. Marks D, Wonderling D, Thorogood M, Lambert H, Humphries SE, Neil HAW. Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2000;4:1–123
  14. Australia and New Zealand Horizon Scanning Network. Genetic screening for familial hypercholesterolaemia. Horizon scanning report. Canberra: Department of Health and Ageing; August 2007.
  15. Cooper A, O’Flynn N On behalf of the Guidelines Development Group. Risk assessment and lipid modifications for primary and secondary prevention of cardiovascular disease: summary of NICE guidance. BMJ. 2008;336:1246–1248
  16. Agard A, Bolmsjo IA, Hermeren G, Wahlstom J. Familial hypercholesterolemia: ethical, practical and psychological problems from the perspective of patients. Patient Educ Counsel. 2005;57:162–167
  17. National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand . Lipid management guidelines. MJA. 2001;175(Suppl.):S57–S85
  18. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002;106:3143–421.
  19. Sullivan D Members of the CSANZ Cardiovascular Genetics Working Group. Guidelines for the diagnosis and management of familial hypercholesterolaemia. Heart Lung Circ. 2007;16:25–27
  20. McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP, et al. Drug therapy of high risk lipid abnormalities in children and adolescents. Circulation. 2007;115:1–20
  21. Wald D. Commentary: controversies in NICE guidance on familial hypercholesterolaemia. BMJ. 2008;337:510–511
  22. Wald DS, Bestwick J, Wald NJ. Child–parent screening familial hypercholesterolaemia: a screening proposal based on a meta-analysis. BMJ. 2007;335:573–574

PII: S1443-9506(08)00926-8

doi: 10.1016/j.hlc.2008.10.012

Heart, Lung and Circulation
Volume 18, Issue 3 , Pages 181-183 , June 2009

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