« Previous
Next »
Heart, Lung and Circulation
Volume 18, Issue 6
, Pages 393-400
, December 2009
p38 Mitogen-Activated Protein Kinase Inhibition Reduces Inflammatory Cytokines in a Brain-Dead Transplant Donor Animal Model
References
- . High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med. 1995;333:333–336
- . Donor brain death reduces survival after transplantation in rat livers preserved for 20
h. Transplantation. 2001;72:1632–1636 - . Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation. 2000;102:2426–2433
- . Pulmonary transplantation: the role of brain death in donor lung injury. Transplantation. 2003;75:1928–1933
- . Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation. 1999;67:343–348
- . Mechanical brain injury: the sympathoadrenal response. J Neurosurg. 1984;61:76
- . Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation. 1998;65:1533–1542
- . Selective overexpression of inflammatory molecules in hearts from brain-dead rats. J Heart Lung Transplant. 2002;21:804–811
- . Blood level of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants. Metabolism. 1995;44:812–816
- . Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med. 2001;163:259–265
- . Tumor necrosis factor-α is expressed in donor heart and predicts right ventricular failure after human heart transplantation. Circulation. 2000;102:326
- . P38 MAPKs: key signaling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov. 2003;2:717–726
- . A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994;265:808–811
- . p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart. Ann Thorac Surg. 2005;80:2235–2241
- . p38 inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells. J Mol Cell Cardiol. 2004;37:1111–1114
- . Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 2001;81:807–869
- . Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. P38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion. Circ Res. 1996;79:162–173
- . Pro-inflammatory cytokines and enviromental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem. 1995;270:7420
- . Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a p38 mitogen-activated protein kinase-dependent mechanism. Surgery. 1998;124:291–296
- . p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function. J Surg Res. 1999;83:7–12
- . An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. J Biol Chem. 1999;274:6272
- . Effect of a p38 mitogen-activated protein kinase inhibitor as an additive to Euro-Collins solution on reperfusion injury in canine lung transplantation. Transplantation. 2002;74:320–326
- . P38α mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats. J Cardiovasc Pharmacol. 2004;44:486–492
- . Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets. Pediatr Crit Care Med. 2004;5:28–34
- . Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003;86:1534–1544
- . The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs). FEBS Lett. 1998;426:93–96
- . Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997;235:533–538
- . The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation. J Heart Lung Transplant. 1996;15:764–777
- . Functional evidence of reversible ischemic injury immediately after the sympathetic storm associated with experimental brain death. J Heart Lung Transplant. 2003;22:922–928
- . Physiologic changes after brain death. J Heart Lung Transplant. 2004;23(9 Suppl.):S223–S226
- . Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts. Circulation. 2000;102:352–358
- . The interleukin-6/interleukin-6-recepter system is activated in donor hearts. J Am Coll Cardiol. 2002;39:1508–1512
- . P38 MAP kinase mediates inflammatory cytokine induction in cardiomyocites and extracellular matrix remodeling in heart. Circulation. 2005;111:2494–2502
- . Hemodynamic mechanisms of lung injury and systemic inflammatory response following brain death in the transplant donor. Am J Transplant. 2005;5:684–693
- . Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death. J Surg Res. 2005;123:118–125
- . Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury. Am J Physiol. 2006;291:H1972–H1977
- . Pharmacological properties of SD-282—an alpha-isoform selective inhibitor for p38 MAP kinase. Pharmacology. 2008;81:204–220
- . Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury. Biol Pharm Bull. 2007;30:460–464
- . Carbon monoxide inhalation ameliorates conditions of lung grafts from rat brain death donors. Chin Med J (Engl). 2008;121:1411–1419
PII: S1443-9506(09)00946-9
doi: 10.1016/j.hlc.2009.05.706
© 2009 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Heart, Lung and Circulation
Volume 18, Issue 6
, Pages 393-400
, December 2009
