Heart, Lung and Circulation
Volume 19, Issue 2 , Pages 75-80 , February 2010

Lipid Profile and Non-enzymic Antioxidant Status in Patients with Acute Coronary Syndrome in South India

  • Priya Gururajan, MSc

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
  • ,
  • Prema Gurumurthy, FABMS, FIMSA, DSc

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 44 42017575/26567200; fax: +91 44 26565150/42180066.
  • ,
  • Pradeep Nayar, DNB (cardio), MMAMS, FACC, FAIMS

      Affiliations

    • Department of Cardiology, Chettinad Hospital and Research Institute, Kelambakkam, India
  • ,
  • M. Chockalingam, DNB

      Affiliations

    • Department of Cardiology, Chettinad Hospital and Research Institute, Kelambakkam, India
  • ,
  • S. Bhuvaneshwari, MSc

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
  • ,
  • Sai Babu, DCP

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
  • ,
  • A. Sarasabharati, FICP, FCCP, FIAMS, FICA, FMMC, FEMSI

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
  • ,
  • Dolice Victor, MSc

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
  • ,
  • K.M. Cherian, FRACS, DSc (Hon), DSc (HC)

      Affiliations

    • International Centre for Cardiothoracic and Vascular Diseases, Department of Cardiology, Dr. K.M. Cherian Heart Foundation (A unit of Frontier LifeLine Pvt Ltd.), R-30 C, Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India

Received 3 June 2009 ,Revised 29 July 2009 ,Accepted 29 July 2009.

References 

  1. Kumar A, Sivakanesan R, Singh S. Oxidative stress, endogenous antioxidant and ischemia modified albumin in normolipidemic acute myocardial infarction patients. J Health Sci. 2008;54(4):482–487
  2. Rajasekhar D, Rao S PVLN , Lateef SAA, Saibaba KSS, Subramanyam . Association of serum antioxidants and risk of coronary artery disease in South Indian population. Indian J Med Sci. 2004;58(11):465–471
  3. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress and antioxidants. A review. J Biochem Mol Toxicol. 2003;17:24–38
  4. Nigam PK. Biochemical markers of myocardial injury. Indian J Clin Biochem. 2007;22(1):10–17
  5. Zimetbaum PJ, Josephson ME. Use of the electrocardiogram in acute myocardial infraction. N Engl J Med. 2003;348:934–935
  6. Omaye ST, Turnbull JD, Sauberil H. Selected methods for the determination of ascorbic acid in animal cells tissues and fluids. In:  McCormick DB,  Wright LD editor. Methods in enzymology. vol. 62:New York: Academic Press Inc.; 1979;p. 1–11
  7. Emmerie A, Engle C. Colorimetric determination of alpha tocopherol. Rev Trab Chim. 1938;57:1351–1355
  8. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882–888
  9. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellmans reagent. Anal Biochem. 1968;25:192–205
  10. Yagi K, Nishigaki I, Ohama H. Vitamins. 1968;39:105
  11. Nigam PK, Narain VS, Hasan M. Serum lipid profile in patients with acute myocardial infarction. Indian J Clin Biochem. 2004;19(1):67–70
  12. Tsimikas S, Bergmark C, Beyer RW. Temporal increases in plasma markers of oxidized low density lipoprotein strongly reflect the presence of acute coronary syndrome. J Am Coll Cardiol. 2003;41:360–370
  13. Vetter NJ, Strange RC, Adams W, Oliver MF. Initial metabolic and hormonal response to acute myocardial infarction. Lancet. 1974;284–289
  14. Ryder REJ, Hayes TM, Mulligan IP, Kingswood JC, Williams S, Owens DR. How soon after myocardial infarction should plasma lipid values be assessed?. Br Med J. 1984;289:1651–1653
  15. Jackson R, Scragg R, Marshall R, White H, O’Brien K, Small C. Changes in serum lipid concentrations during first 24, hours after myocardial infarction. Br. Med. J. 1987;294:1588–1589
  16. Heldenburg D, Rubenstein A, Levtov O, Berns L, Werbin B, Tamir I. Serum lipids and lipoprotein concentrations during the acute phase of myocardial infarction. Atherosclerosis. 1980;35:433–437
  17. Tamer L, Sucu N, Polat G, Ercan B, Aytacoglu B, Yucebilgic G, et al. Decreased serum total antioxidant status and erythrocyte-reduced glutathione levels are associated with increased serum malondialdehyde in atherosclerotic patients. Archives of Medical Research. 2002;33:257–260
  18. Farombi EO, Olowg BI, Emerole GO. Effect of three structurally related antimalaria drugs on liver microsomal components and lipid peroxidation in rats comp. Biochem Physiol. 2000;126:217–224
  19. Vita JA, Kaeney JF, Raby KE, Morrow JD, Freedman JE, Lynch S, et al. Low plasma ascorbic acid independently predicts the presence of an unstable angina. J Am Coll Cardiol. 1998;31:980–986
  20. Nyyssonen K, Parviainen MT, Salonen R, Tuomilehto J, Salonen JT. Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. BMJ. 1997;314:634–638
  21. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part 1). N Engl J Med. 1992;326:242–250
  22. Kaur K, Bedi G, Kaur M, Vij A, Kaur I. Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease. Indian J Clin Biochem. 2008;23(1):33–37
  23. Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerotic heart disease. N Engl J Med. 1997;337:408–417
  24. Keaney JF, Vita JA. Atherosclerosis, oxidative stress and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis. 1995;38:129–154
  25. Nwanjo HU, Oze G, Okafor MC, Nwosu D, Nwankpa P. Oxidative stress and non-enzymic antioxidant status in hypertensive patients in Nigeria. Afr J Biotechnol. 2007;14(6):1681–1684
  26. Ferrari R, Ceconi C, Curello S, Guanieri C, Caldarera CM, Albertini A, et al. Oxygen- mediated myocardial damage during ischemia and reperfusion: Role of the cellular defenses against oxygen toxicity. J Mol Cell Cardiol. 1985;17:937–945
  27. Riemersma RA, Carruthers KF, Elton RA, Fox KAA. Vitamic C and risk of myocardial infarction. Am J Clin Nutr. 2000;71:1181–1186
  28. Kumar A, Sivakanesan R, Gunasekara S. Oxidative stress and antioxidant status in normolipidemic AMI patients. Indian J Clin Biochem. 2008;23(3):296–298
  29. Liu S, Lee IM, Song Y, Van Denburgh M, Cook NR, Manson JAE, et al. Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes. 2006;55:2856–2862
  30. Ghosh J, Mishra TK, Rao YN, Aggarwal SK. Oxidized LDL, HDL Cholesterol, LDL cholesterol levels in patients of coronary artery disease. Indian J Clin Biochem. 2006;21(1):181–184

PII: S1443-9506(09)01056-7

doi: 10.1016/j.hlc.2009.07.003

Heart, Lung and Circulation
Volume 19, Issue 2 , Pages 75-80 , February 2010