Heart, Lung and Circulation
Volume 19, Issue 2 , Pages 93-95 , February 2010

Cardiac Isoform of Alpha 2 Macroglobulin and Its Reliability as a Cardiac Marker in HIV Patients

  • Ramasamy Subbiah, PhD

      Affiliations

    • Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    • Department of Biochemistry, Temple University, Philadelphia, PA, USA
    • These authors equally contributed to this work.
    • ,
  • Vipindas Chengat, MD

      Affiliations

    • Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL, USA
    • Department of Medicine, Madurai Medical College, India
    • These authors equally contributed to this work.
    • ,
  • Justin D. Clifton, PhD

      Affiliations

    • Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    • ,
  • Andiappan Rathinavel, PhD

      Affiliations

    • Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    • Department of Cardio Thoracic Surgery, Madurai Medical College, Madurai, India
    • ,
  • Aurelian Bidulescu, PhD

      Affiliations

    • Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
    • Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    • ,
  • Ramprasath Tharmarajan, MSc

      Affiliations

    • Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    • ,
  • Govindan Sadasivam Selvam, PhD

      Affiliations

    • Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    • Corresponding Author InformationCorresponding author at: Department of Biochemistry, Center for Advanced Studies in Functional Genomics, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India. Tel.: +91 452 2458223; fax: +91 452 2458223.

Received 19 July 2009 ,Revised 19 October 2009 ,Accepted 19 October 2009.

References 

  1. Barbaro G, Di Lorenzo G, Grisorio B. Cardiac involvement in the acquired Immunodeficiency syndrome: a multicenter clinical–pathological study. AIDS Res Hum Retroviruses. 1998;79:599–604
  2. Bozzette S, Ake CF, Tam HK. Cardiovascular and cerebrovascular events in patients treated for human immunodeficiency virus infection. N Eng J Med. 2003;348:702–710
  3. Lipshultz SE, Easley KA, Orav J. Left ventricular structure and function in children infected with human immunodeficiency virus: the Prospective P2C2 HIV Multicenter Study. Circulation. 1998;97:1246–1256
  4. Hubbard J. Common biochemical markers for diagnosing heart disease. Nurs Times. 2003;99(26):24–25
  5. Mariappan M, Selvamurgan N, Rajamanickam C. Purification and characterization of a high molecular weight protein induced in rat serum during the development of cardiac hypertrophy. Arch Biochem Biophys. 1994;315:558
  6. Rathinavel A, Dhandapani PS, Annapoorani P, Ramasamy S, Selvam GS. Cardiac isoform of alpha-2 macroglobulin as a novel marker for cardiac diseases. Eur J Cardiovasc Prev Rehabil. 2005;12:601–603
  7. Annapoorani P, Dhandapany PS, Sadayappan S, Ramasamy S, Rathinavel A, Selvam GS. Cardiac isoform of alpha-2 macroglobulin—a new biomarker for myocardial infracted diabetic patients. Atherosclerosis. 2006;186:173–176
  8. Ramasamy S, Omnath R, Rathinavel A, Kannan P, Dhandapany PS, Annapoorani P, et al. Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients. AIDS. 2006;20:1979–1981
  9. Prabhakar R, Rajamanickam C. Serum protein of 135-kDa molecular weight—a molecular signal for cardiac hypertrophy. Arch Biochem Biophys. 1993;302:425–430
  10. Harlow E, Lane DP. Antibodies—a laboratory manual. Cold Spring Harbor Laboratory Press; 1988;
  11. Rajamanickam C, Sakthivel S, Kurian Joseph P, Athimoolam Janarthanan R. A novel serum protein of molecular weight 182kDa: a molecular marker for an early detection of increased left ventricular mass in patients with cardiac hypertrophy. J Cardiovasc Risk. 1998;5:335–338
  12. Al-Attar I, Orav EJ, Vernat E, Vlach SA, Lipshultz SE. Predictors of cardiac morbidity and related mortality in children with acquired immunodeficiency syndrome. J Am Coll Cardiol. 2003;41:1598–1605
  13. Barbaro G. Cardiovascular manifestations of HIV infection. J R Soc Med. 2001;94:384–390
  14. Rajappa M, Sharma A. Biomarkers of cardiac injury: an update. Angiology. 2005;56(6):677–691

PII: S1443-9506(09)01089-0

doi: 10.1016/j.hlc.2009.10.005

Heart, Lung and Circulation
Volume 19, Issue 2 , Pages 93-95 , February 2010

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