Heart, Lung and Circulation
Volume 19, Issue 4 , Pages 234-242 , April 2010

Serum Thromboxane B2 Compared to Five Other Platelet Function Tests for the Evaluation of Aspirin Effect in Stable Cardiovascular Disease

  • Giselle Kidson-Gerber, FRACP, FRCPA

      Affiliations

    • South Eastern Area Laboratory Services (SEALS), Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    • University of New South Wales, Faculty of Medicine, Sydney, Australia
    • Corresponding Author InformationCorresponding author at: Department of Haematology, SEALS, Level 4, Campus Centre, Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia. Tel.: +61 2 9382 9047; fax: +61 2 9382 9247.
  • ,
  • James Weaver, FRACP

      Affiliations

    • University of New South Wales, Faculty of Medicine, Sydney, Australia
    • Department of Cardiology, St George Hospital, Sydney, Australia
  • ,
  • Rosalie Gemmell, BApSci

      Affiliations

    • SEALS, Department of Haematology, St George Hospital, Sydney, Australia
  • ,
  • Ananth M. Prasan, FRACP, PhD

      Affiliations

    • University of New South Wales, Faculty of Medicine, Sydney, Australia
    • Department of Cardiology, St George Hospital, Sydney, Australia
  • ,
  • Beng Hock Chong, FRACP, FRCPA, PhD, FRCP

      Affiliations

    • University of New South Wales, Faculty of Medicine, Sydney, Australia
    • SEALS, Department of Haematology, St George Hospital, Sydney, Australia

Received 24 August 2009 ,Revised 9 November 2009 ,Accepted 11 November 2009.

References 

  1. de Gaetano G Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet. 2001;357:89–95
  2. Aspirin Trialists’ Collaboration . Collaborative overview of randomized trials of antiplatelet therapy. Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J. 1994;308:81–106
  3. Krasopoulos G, Brister S, Beattie W, Buchanan M. Aspirin “resistance” and risk of cardiovascular morbidity systematic review and meta-analysis. Br Med J. 2008;336:195–198
  4. Snoep J, Hovens M, Eikenboom J, van der Bom J, Huisman M. Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events. Arch Intern Med. 2007;167(15):1593–1599
  5. Lordkipanidze M, Pahrand C, Schampaert E, Turgeon J, Palisatis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary heart disease. Eur Heart J. 2007;28:1702–1708
  6. Perneby C, Hakan Wallen N, Rooney C, Fitzgerald D, Hjemdahl P. Dose- and time-dependent antiplatelet effects of aspirin. Thromb Haemost. 2006;95:652–658
  7. Ivandic BT, Giannitsis E, Schlick P, Staritz P, Katus HA, Hohlfeld T. Determination of aspirin responsiveness by use of whole blood platelet aggregometry. Clin Chem. 2007;53:614–619
  8. Poulsen T, Kristensen S, Atar D, Mickley H. A critical appraisal of the phenomenon of aspirin resistance. Cardiology. 2005;104:83–91
  9. Dyskiewicz-Korpanty AM, Frenkel EP, Sarode R. Approach to the assessment of platelet function: comparison between optical-based platelet-rich plasma and impedance-based whole blood platelet aggreagation methods. Clin Appl Thromb/Hemost. 2005;11(1):25–35
  10. Gonzalez-Conejero R, Rivera J, Corral J, Acuna C, Guerrero JA, Vicente V. Biological assessment of aspirin efficacy on healthy individuals: heterogenous response or aspirin failure?. Stroke. 2005;36:276–280
  11. Ohmori T, Yatomi Y, Nonaka T, Kobayashi Y, Madoiwa S, Mimuro J, et al. Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signalling pathway(s) in cardiovascular events of aspirin-treated patients. J Thromb Haemost. 2006;4:1271–1278
  12. Gengo F, Bates V, Rainka M, Gengo M. Aspirin resistance in office patients treated for secondary stroke prophylaxis. Stroke. 2006;37(2):715
  13. Chakroun T, Addad F, Abderazek F, ben-Farhat M, Hamdi S, Gamra H, et al. Screening for aspirin resistance in stable coronary artery patients by three different tests. Thromb Res. 2007;121(3):413–418
  14. Gum P, Kottke-Marchant K, Poggio E, Gurm H, Welsh P, Brooks L, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cardiol. 2001;88:230–235
  15. Gurbel P, Bliden K, DiChiara J, Newcomer J, Weng W, Neerchal N, et al. Evaluation of dose-related effects of aspirin on platelet function. Results from the Aspirin-Induced Platelet Effect (ASPECT) Study. Circulation. 2007;115:3156–3164
  16. Harrison P, Degal H, Blasbery K, Furtado C, Silver L, Rothwell P. Screening for aspirin responsiveness after transient ischemic attack and stroke, comparison of 2 point-of-care platelet function tests with optical aggregometry. Stroke. 2005;36:1001–1005
  17. Cattaneo M. Laboratory detection of ‘aspirin resistance’ what test should we use (if any)?. Eur Heart J. 2007;28:1673–1675
  18. Maree A, Fitzgerald D. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation. 2007;115:2196–2207
  19. Coomber BL, Mitchell GB, Starr AE, Minhas K, Tamblyn A, Shewen PE, et al. Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia. Vet J. 2006;171(1):126–134
  20. Gasparyan AY, Watson T, Lip G. The role of aspirin in cardiovascular prevention. J Am Coll Cardiol. 2008;51:1829–1843
  21. Din J, Newby D, Flapan A. Omega 3 fatty acids and cardiovascular disease – fishing for a natural treatment. Br Med J. 2004;328:30–35
  22. Hooper L, Thompson R, Harrison R, Summerbell C, Ness A, Moore H, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. Br Med J. 2006;332(7544):752–760
  23. Nair G, Connolly S. Should patients with cardiovascular disease take fish oil?. Can Med Assoc J. 2008;178(2):181–182
  24. Mori T, Beilin L, Burke V, Morris J, Ritchie J. Interactions between dietary fat, fish, fish oils and their effects on platelet function in men at risk of cardiovascular disease. Arterioscl Thromb Vascul Biol. 1997;17(2):279–286
  25. Pirich C, Gaszo A, Granegger S, Sinzinger H. Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. Thromb Res. 1999;96(3):219–227
  26. Engstrom K, Wallin R, Saldeen T. Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. Prostagland Leukot Essent Fatty Acids. 2001;64(6):291–297
  27. Horiuchi H. Recent advances in antiplatelet therapy: the mechanisms, evidence and approach to the problems. Ann Med. 2006;38(3):162–172
  28. Vermiere E. Patient adherence to therapy: 3 decades of research. J Clin Pharmacol Therap. 2001;26:331–342
  29. Biondi-Zoccai G, Lotrionte M, Agostoni P, Abbate A, Fusaro M, Burzotta F, et al. A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50279 patients at risk for coronary artery disease. Eur Heart J. 2006;27:2667–2674
  30. Lepantalo A, Mikkelsson J, Resendiz JC, Viiri L, Backman J, Kankuri E, et al. Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thromb Haemost. 2006;95:253–259
  31. Cohen H, Crandall J, Hailpern S, Billett H. Aspirin resistance associated with HBA1c and obesity in diabetic patients. J Diab Comp. 2008;22:224–228
  32. Manoharan A, Gemmell R, Hartwell T. Use of whole blood platelet lumi-aggregometry to optimize anti-platelet therapy in patients with chromic myeloproliferative disorders. Am J Haematol. 2006;81:676–683
  33. Ivandic BT, Schlick P, Staritz P, Kurz K, Katus H, Giannitsis E. Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the P2Y12 receptor. Clin Chem. 2006;52(3):383–388

PII: S1443-9506(09)01103-2

doi: 10.1016/j.hlc.2009.11.002

Heart, Lung and Circulation
Volume 19, Issue 4 , Pages 234-242 , April 2010