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A Regulatable Model of Mutant α-Myosin Heavy Chain Overexpression to Study the Structural and Functional Consequences of Hypertrophy Regression
Left ventricular hypertrophy (LVH) is a significant cause of morbidity and mortality, but whether its prevention or regression is feasible and/or beneficial is unclear. We generated an αMHC403/+-tTA m...
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L. Cannon,
T. Marciniec,
B. Mearns,
M. Vale,
V. Nikolova-Krstevski,
S. Kesteven,
S. Raynor,
M. Feneley,
R. Graham,
D. Fatkin
et al.
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S1
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Molecular Imaging of Acute Thrombosis and Thrombolysis by Contrast Enhanced Ultrasound with Novel Platelet-targeted Microbubbles
Background: Molecular imaging is a rapidly emerging enabling technology allowing non-invasive detection of vascular pathologies. However, imaging technologies offering a high resolution are currently ...
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X. Wang,
C. Hagemeyer,
F. Jia,
E. Leitner,
I. Ahrens,
K. Peter
et al.
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S1
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Obesity Results in Progressive Atrial Electrical and Structural Remodeling: Implications for Atrial Fibrillation
Background: Obesity has been associated with the development of atrial fibrillation (AF); however the mechanisms by which it results in a pro-arrhythmic substrate remain unknown.
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H. Abed,
P. Kuklik,
D. Kelly,
A. Nelson,
S. Worthley,
W. Abhayaratna,
G. Wittert,
P. Sanders
et al.
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S2
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Evidence for an Acute Diffuse Fibrotic Response Throughout the Left Ventricle Following Acute Myocardial Infarction
Introduction: A fundamental process in the development of ischaemic cardiomyopathy is left ventricular (LV) remodeling, characterised by structural and functional abnormalities throughout the entire m...
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W. Chan,
S. Duffy,
A. Ellims,
A. Dart,
A. Taylor
et al.
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S2
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Global Longitudinal Strain is a Strong Independent Predictor of All-Cause Mortality in Patients with Aortic Stenosis
Background: Global longitudinal strain (GLS), measured with speckle tracking echocardiography, is a sensitive marker of LV systolic function, however its prognostic capacity in patients with aortic st...
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L. Kearney,
M. Ord,
G. Matalanis,
K. Lu,
K. Profitis,
L. Burrell,
P. Srivastava
et al.
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S3
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The Index of Microcirculatory Resistance Predicts Myocardial Infarction Related to Percutaneous Coronary Intervention
Background: Periprocedural myocardial infarction (PMI) related to percutaneous coronary intervention (PCI) is prevalent and portends poor outcomes. There is currently no clinically applicable method t...
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A. Yong,
M. Ho,
M. Shah,
C. Chawantanpipat,
R. O’Connell,
A. Keech,
L. Kritharides,
W. Fearon,
M. Ng
et al.
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S3
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A Cost-effectiveness Analysis of Genetic Testing in the Evaluation of Families with Hypertrophic Cardiomyopathy
Background: Traditional management of families with hypertrophic cardiomyopathy (HCM) involves periodic lifetime clinical screening, an approach that does not identify all gene carriers. Cost limitati...
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J. Ingles,
J. McGaughran,
P. Scuffham,
J. Atherton,
C. Semsarian
et al.
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S4
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Efficacy of a Pharmacist-Managed Intervention for Improved Blood Pressure Control in Patients with Elevated Cardiovascular Disease Risk: Subgroup Analysis of the HAPPY RCT
The Hypertension Adherence Program in Pharmacy (HAPPY) was a randomised controlled trial conducted in 60 Australian community pharmacies. The project compared changes to medicines adherence and blood ...
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K. Mc Namara,
K. Stewart,
J. George,
S. Jackson,
G. Peterson,
J. Hughes,
M. Bailey,
A. Hsueh,
L. Bereznicki,
P. Gee,
R. Lau,
D. Bortoletto,
J. McDowell
et al.
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S4
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Evaluation of Right Ventricular Volume and Systolic Function – A Comparison of 2 and 3-Dimensional Echocardiography with Cardiac Magnetic Resonance
Background: Cardiac magnetic resonance (CMR) is the gold standard for non-invasive assessment of right ventricular (RV) size and function, but is limited by its availability. Real time 3D echocardiogr...
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J. Chen,
K. Profitis,
K. Lu,
S. Harberts,
M. Ord,
I. Vujacic,
L. Kearney,
P. Calafiore,
G. Smith,
M. Molan,
E. Jones,
P. Srivastava
et al.
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S5
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Risk Reduction Interventions in Atrial Fibrillation: A Systematic Review
Background: Approximately 240,000 Australians live with atrial fibrillation (AF), many having multiple cardiovascular risk factors and high stroke risk, but most are not included in structured risk re...
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N. Lowres,
L. Neubeck,
B. Freedman,
T. Briffa,
A. Bauman,
J. Redfern
et al.
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S5
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Access to Cardiac Rehabilitation and Secondary Prevention Services in Australia: Is Geography Really the Issue?
Background/Aims: Timely access is critical for optimising outcomes after a cardiac event. In Australia the overall attendance at cardiac rehabilitation remains low and in some communities’ access to b...
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R. Clark,
N. Coffee,
D. Turner,
K. Eckert,
v. Deborah,
S. Stewart,
D. Wilkinson,
A. Tonkin
et al.
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S6
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Acetazolamide Reduces Hospital Admissions and Length of Stay in Refractory Heart Failure Patients
Background: End stage Heart Failure patients with refractory oedema have frequent hospital admissions and increased length of stay (LOS) with resultant morbidity, mortality and cost, despite optimal m...
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M. Lucas,
M. Brown
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S6
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Sex Differences in Symptom Presentation in Acute Myocardial Infarction: A Systematic Review and Meta-analysis
Background: Recognition of sex differences in symptom presentation of acute myocardial infarction (AMI) is important for timely clinical diagnosis. We sought to address two research questions in our r...
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L. Coventry,
J. Finn,
A. Bremner
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S6-S7
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Wandering Hearts: Acute Cardiac Management in the Regional Setting
Evidence has demonstrated the disparity between the burden of disease for rural and urban Australians. Many studies have investigated the cause and ramifications of this disparity. However, few have s...
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S. Clune,
M. Murphy,
J. Blackford
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S7
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Chronic Low Dose Δ9-Tetrahydrocannabinol Administration Prevents Functional and Electrophysiological Myocardial Changes in SHR and SHR/STZ Rats by Antioxidant and Anti-inflammatory Mechanisms
It is well established that oxidative stress and inflammation initiate cardiovascular dysfunction associated with poorly managed hypertension and diabetes. The aim of this study was to examine the ant...
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R. Vella,
A. Fenning
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S7
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In Situ Measurements of Cross-bridge Dynamics and Lattice Spacing in Diabetic Rat Hearts using X-ray Diffraction
Independent of hypertension and coronary artery disease diabetes is associated with a specific diabetic cardiomyopathy. The use of synchrotron radiation (SR) as a source for small-angle X-ray diffract...
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M. Jenkins,
A. Edgley,
T. Sonobe,
Y. Fujii,
H. Ishibashi-Ueda,
D. Kelly,
D. Schwenke,
N. Yagi,
M. Shirai,
J. Pearson
et al.
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S8
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Losartan Improves Survival and Cardiac Function in a Double-mutant Mouse Model of Severe Hypertrophic Cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is an inherited disease of the myocardium, caused by sarcomere protein mutations. Five percent of HCM patients harbour multiple mutations leading to a mor...
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R. Shephard,
T. Tsoutsman,
C. Semsarian
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S8
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Phosphoinositide 3-Kinase p110alpha is a Master Regulator of Exercise-induced Cardiac Protection, Acting Independently of Heat Shock Protein 70
Background: Molecular mechanisms that mediate exercise-induced cardiac protection are not well defined. We hypothesised that phosphoinositide 3-kinase p110α (PI3K) is critical for exercise-induced pro...
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K. Weeks,
X. Gao,
H. Kiriazis,
M. Febbraio,
X. Du,
J. McMullen
et al.
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S8-S9
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2011 Draft Position Statement on the Use of Ambulatory Blood Pressure Monitoring in Australia: National Heart Foundation (NHF) & High Blood Pressure Research Council (HBPRCA)
Due to confidentiality reasons, the text of this abstract has been withheld from publication.
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G. Head,
A. Mangoni,
M. Nelson,
D. Cowley,
M. Stowasser,
B. McGrath,
A. Mihailidou,
M. Schlaich,
J. Wilson,
L. Ruta
et al.
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S9
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A Novel Framework to Assess Neural and Peripheral Characteristics in Hypertension using Baroreflex Equilibrium Diagram
Background: Sympathetic nervous hyperactivity as well as the cardiovascular abnormality (arterial atherosclerosis and cardiac hypertrophy) has long been suspected to contribute to the pathogenesis of ...
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Y. Sata,
T. Kawada,
M. Sugimachi
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S9-S10
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A Novel Recombinant CD39 Targeting Activated Platelets via a Fused Single-chain Antibody: Achieving Efficient Anti-coagulation While Minimising Bleeding Side Effects by Clot Directed Enrichment
Introduction: CD39, an NTPDase with strong antithrombotic properties, has previously been shown to be protective in models of stroke, transplantations, pulmonary embolism and myocardial infarctions by...
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J. Hohmann,
S. Krajewski,
F. Jia,
H. Nandurkar,
A. Straub,
K. Peter
et al.
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S10
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Acute Pulmonary Embolism (PE)—Is Echocardiography Underutilised in Regional Australia
Background: Echocardiography is recommended after acute pulmonary embolisms (PE) to risk stratify patients at risk of developing chronic thromboembolic pulmonary hypertension (CTEPH) and then at six t...
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V. Tyagi,
N. Kutaiba,
M. Yates
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S10-S11
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Assessment of Optimal Cell Therapy for the Angiogenesis Response in a Murine Hindlimb Ischaemia Model using CD34+ cells and Endothelial Progenitor Cells
Purpose: Therapeutic angiogenesis using stem/progenitor cells has been the focus of recent research. CD34+ cells and endothelial progenitor cells (EPCs) have been found to promote angiogenesis. This s...
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C. Hsu,
R. Chow,
L. Dunn,
K. Chan,
M. Guillou,
D. Celermajer,
M. Ng
et al.
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S11
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Association of Left Ventricular Motion and Central Blood Pressure Waveform Morphology
Background: Central blood pressure is a determinant of cardiovascular outcome however it can be described by parameters other than systolic and diastolic pressure with central augmentation index (AIx)...
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K. Cheng,
J. Cameron,
M. Tung,
P. Mottram,
I. Meredith,
S. Hope
et al.
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S11
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Augmentation Index (AIx) and Augmentation Pressure (AP) in a Cardiac Population
Background: Arterial stiffness and pressure wave reflection are associated with cardiovascular risk. The AIx is the proportion of central aortic pulse pressure that is attributed to the reflected puls...
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L. Wong,
E. Shanehsaz,
T. Hong,
J. Chiha,
P. Kovoor,
P. Mitchell,
A. Thiagalingam
et al.
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S11-S12
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This abstract has been withdrawn.
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S12
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Calibration of Carotid Central Pressures: A Flaw in Brachial Applanation Tonometry?
Central pressure, based on carotid and brachial applanation tonometry (AT) does not predict outcomes. This may be due to inaccuracy of brachial and carotid AT. No validation has been published.
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A. Adji,
M. O’Rourke
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S12
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Correlation Between Radial Artery- and Peripheral Arterial Tonometry Derived Augmentation Index in Patients with Atrial Fibrillation
Introduction: Augmentation index (AI) measures the contribution that wave reflection makes to the arterial pressure waveform. AI is considered a surrogate marker for the stiffness of the arterial syst...
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S. Willoughby,
D. Lau,
C. Schultz,
H. Lim,
R. Mahajan,
S. Nayyar,
M. Worthley,
P. Sanders
et al.
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S12-S13
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Does Resveratrol Prevent Maladaptive Electrophysiological and Vascular Alterations in l-NAME Induced Hypertensive Rats?
Resveratrol has demonstrated various possible cardio-protective mechanisms, which may prove to be beneficial in the treatment and prevention of various complications seen in conditions such as diabete...
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C. Pullen,
A. Fenning,
F. Coulson,
R. Vella,
K. Connolly,
D. Jackson
et al.
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S13
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Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo
In diabetes, long term micro- and macro-vascular damage often underlies the functional decline in a number of organs. Using synchrotron imaging we are now able to detect small vessel calibres (∼40μm v...
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M. Jenkins,
A. Edgley,
T. Sonobe,
R. Brown,
Y. Fujii,
D. Kelly,
K. Umetani,
D. Schwenke,
M. Shirai,
J. Pearson
et al.
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S13-S14
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Effect of Adenosine on Pulmonary Vascular Resistance in Patients with Pulmonary Hypertension due to Left Heart Disease and Scleroderma
Introduction: Functional assessment of the pulmonary vasculature is an important tool in the diagnosis of pulmonary hypertension. The effect of adenosine on pulmonary haemodynamics in left heart disea...
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A. Burns,
S. Murch,
J. Layland,
A. La Gerche,
A. MacIsaac,
D. Prior
et al.
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S14
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Gender Differences in Internal Mammary Artery Vasoconstrictor Responses
Background: Women have poorer in-hospital outcomes following coronary artery bypass grafting compared with men although the reasons are unclear. Gender-mediated differences in the vascular reactivity ...
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A. Jaghoori,
R. Stuklis,
M. Worthington,
J. Edwards,
D. Wilson,
J. Beltrame
et al.
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S14-S15
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Heme Oxygenase-1 is Necessary for Ischaemia-mediated Neovascularisation
Due to confidentiality reasons, the text of this abstract has been withheld from publication.
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K. Chan,
M. Guillou,
L. Dunn,
R. Midwinter,
J. Ni,
Y. Wang,
R. Stocker,
M. Ng
et al.
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S15
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Left Atrial Specific Endothelial Dysfunction and Inflammation in Atrial Fibrillation
Introduction: Atrial fibrillation (AF) is associated with a prothrombotic state, with thrombus formation frequently occurring within the left atria (LA). We have previously shown that platelet reactiv...
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C. Schultz,
S. Willoughby,
H. Lim,
M. Alasady,
D. Lau,
R. Mahajan,
S. Nayyar,
K. Roberts-Thomson,
G. Young,
P. Sanders
et al.
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S15
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Lipid-free Apolipoprotein A-I Enhances Endothelium generation from Human Blood Monocytes
We have recently reported that human blood monocytes are capable of rapidly transforming into endothelial-like cells after adhering to preexisting endothelium. This indicates that blood monocytes are ...
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C. Tso,
K. Rye,
P. Barter
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S15
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Novel Use of Intra-arterial Doppler in the Assessment of Pulmonary Artery Flow Velocities—Observations Before and After Therapy for Pulmonary Arterial Hypertension
Background: Intra-arterial Doppler is a novel technique which enables accurate assessment of blood flow haemodynamics. We evaluated the feasibility of using intra-arterial Doppler for insights into th...
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N. Iyer,
E. Lau,
D. Celermajer
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S16
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Optimising Primary Care Management of Hypertension: The Valsartan Intensified Primary Care Reduction of Blood Pressure (VIPER-BP) Study
Background: We undertook Australia's largest ever randomised trial of integrated BP and risk reduction management (involving automated absolute risk profiling, standardised pharmacological treatment a...
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S. Stewart,
M. Carrington,
C. Swemmer,
N. Kurstjens,
G. Jennings
et al.
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S16
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Osteopenia and Osteoporosis in a Hypertensive Population
Introduction: Hypertension is a common risk factor for coronary artery disease and stroke, two serious causes of cardiovascular morbidity and mortality. Osteoporosis related hip fractures result in pa...
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N. Agarwal,
S. Agarwal
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S16-S17
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Presence of Subclinical Anxiety in Hypertensive Patients
Introduction: Both hypertension and anxiety are common medical conditions. Since anxiety is associated with an increased incidence of sudden death, its presence in hypertensive patients may have progn...
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N. Agarwal,
S. Agarwal
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S17
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Prevalence of Atrial Fibrillation and Left Ventricular Hypertrophy in the Valsartan Intensified Primary Care Reduction of Blood Pressure (VIPER-BP) Study Cohort
Background: There are few large-scale studies of the prevalence of atrial fibrillation (AF) and left ventricular hypertrophy (LVH) in hypertensive individuals being managed in primary care; both are p...
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S. Stewart,
M. Carrington,
C. Swemmer,
N. Kurstjens,
G. Jennings
et al.
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S17
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Prevalence, Associations and Risk Factors for Orthostatic Hypotension in Medical, Surgical and Trauma Inpatients: An Observational Cohort Study
Introduction: Orthostatic hypotension (OH) is prevalent in hospitalised elderly patients. It can lead to syncope and falls. Age, diabetes, hypertension, multiple co-morbidities and ≥3 antihypertensive...
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A. Aung,
S. Corcoran,
V. Nagalingam,
E. Paul,
H. Newnham
et al.
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S17-S18
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Primary Hypoplasia of Aortic Arch (phaa)—An Update
Primary Hypoplasia of Aortic Arch (phaa) has been linked with hypertension (hbp) in the young adult through the association of Ohm's and Poiseuille's law relating resistance to flow in the aorta. Four...
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T. Goh
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S18
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Reduced Exercise Tolerance in Patients with Increased Aortic Stiffness Assessed by 320-slice Computed Tomography
Background: Increased aortic stiffness is associated with decreased exercise capacity and adverse cardiovascular outcome. It improves prediction when added to conventional cardiovascular risk factors....
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S. Hope,
S. Seneviratne,
S. Lockwood,
J. Cameron
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S18-S19
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Renal Denervation for Refractory Hypertension
Background: Sympathetic activation is a cardinal feature of chronic renal failure (CRF) and contributes to poor cardiovascular outcomes. Both efferent and afferent renal nerves play a crucial role in ...
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A. Walton,
M. Esler,
H. Krum,
M. Schlaich
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S19
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Retrospective Audit of Hypertension Management in a Chronic Disease Management Unit at a Major Tertiary Hospital in Australia
Hypertension is a known cardiovascular risk factor and treatment has been shown to reduce cardiovascular morbidity and mortality. The objective of this study was to evaluate hypertensive management in...
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T. Butler,
H. Newnham,
M. Bonollo
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S19
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Risk Predictors of Lower-limb Amputation in Patients with Type 2 Diabetes Mellitus in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
Introduction: Lower limb amputations associated with type 2 diabetes have major implications for morbidity and mortality. The aim of this analysis was to identify important risk predictors for future ...
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K. Rajamani,
L. Li,
J. Best,
M. Voysey,
R. Ting,
M. D’Emden,
M. Laakso,
J. Baker,
A. Keech
et al.
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S20
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Single-pill Combination of Telmisartan 80 mg/Amlodipine 10mg Provides Superior Blood Pressure Reductions in Patients with Severe Hypertension: Teamsta Severe HTN Study
Purpose: Investigate the efficacy and safety of the single-pill combination of telmisartan 80mg/amlodipine 10mg (T80/A10) vs. its respective monotherapy components in patients with severe hypertension...
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J. Neutel,
G. Mancia,
H. Black,
B. Dahlöf,
H. Defeo,
L. Ley,
R. Vinisko
et al.
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S20-S21
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Sleep Disordered Breathing in Children is Associated with Increased Platelet Aggregation, Systemic Inflammation and Endothelial Dysfunction
Introduction: Sleep disordered breathing (SDB) in adults is an independent risk factor for coronary artery disease and stroke. Altered platelet reactivity, endothelial dysfunction and inflammation in ...
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S. Willoughby,
C. van den Heuvel,
A. Chin,
G. Hodge,
J. Martin,
A. Nelson,
M. Worthley,
D. Kennedy
et al.
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S21
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This abstract has been withdrawn
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S21
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The Number and Function of Late Outgrowth Endothelial Cells Correlate with the extent of Coronary Artery Disease
Due to confidentiality reasons, the text of this abstract has been withheld from publication.
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K. Chan,
P. Simpson,
A. Yong,
C. Chawantanpipat,
C. Hsu,
P. Lim,
L. Dunn,
M. Ng
et al.
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S21
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The Number and Function of Late Outgrowth Endothelial Cells Correlate with the Extent of Coronary Collateralisation in Humans
Due to confidentiality reasons, the text of this abstract has been withheld from publication.
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K. Chan,
P. Simpson,
A. Yong,
C. Chawantanpipat,
C. Hsu,
P. Lim,
L. Dunn,
M. Ng
et al.
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S21
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The Spatio-temporal Distribution of Migrating Pericytes in a Rat Model of Stroke: The Expression of Definitive Cell Markers
In ischaemic brain and myocardium, activated cells play an important role in reperfusion, control of blood flow, reduction of reactive oxygen species and angiogenesis. In the spontaneous hypertensive ...
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V. Sharma,
T. Ling,
P. Wookey,
S. Rewell,
D. Howells,
D. Hare
et al.
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S21-S22
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A New Cardiac Catheterisation Laboratory in Northern NSW: Experiences of the First Year
Lismore Base Hospital is the major referral centre for the Northern NSW Local Heath Network. With increasing demand for cardiac services in the region, a new cardiac catheter laboratory was commission...
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D. Murdoch,
H. Gibbs,
A. Blenkhorn,
D. Mumford,
P. Kwan
et al.
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S22
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A Novel Targeted Recombinant Plasminogen Activator Allows Efficient and Safe Simultaneous Blockage of Activated Platelets and Fibrinolysis
Fibrinolysis has been proven to be beneficial in patients with acute myocardial infarction, stroke, pulmonary embolism and vein thrombosis. However, fibrinolytic drugs, especially when combined with a...
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C. Hagemeyer,
F. Jia,
V. Wong,
D. Yohakim,
D. Huang,
X. Wang,
K. Peter
et al.
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S22
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A Randomised Double-blinded Pilot Study to Assess the Effect of Tetrahydrobiopterin and Folic Acid on Macrovascular and Microvascular Dynamic Function using Cardiovascular Magnetic Resonance
Tetrahydrobiopterin (BH4) is an essential cofactor for the synthesis of endothelial nitric oxide while folic acid prevents BH4 oxidation and scavenges endothelial superoxides. Recent studies have demo...
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B. Paul,
D. Wong,
A. Mangoni,
A. Nelson,
B. Dundon,
S. Willoughby,
S. Worthley,
M. Worthley
et al.
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S23
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A Review of Missed AMI in Public Hospitals
Missed ST elevation myocardial infarction (STEMI) is associated with a high mortality and morbidity. Common features of delay in treatment are not well documented in the Australian environment.
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L. Savage,
S. Turner,
T. Williams
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S23
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Aboriginal Delays in Acute Coronary Syndrome Response and Disparities in Medical Procedures: Understanding the Linkage and Issues for Aboriginal Patients and Health Providers
Due to confidentiality reasons, the text of this abstract has been withheld from publication.
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K. Taylor,
J. Katzenellenbogen,
F. Sanfilippo,
M. Hobbs,
T. Briffa,
L. Dimer,
P. Thompson,
S. Thompson
et al.
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S23
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Acute Predict: Initial Experience in the Midland Region. Comparison of Acute Coronary Syndrome (ACS) Management at an Interventional and Non-interventional Centre
Background: ACUTE PREDICT, a web based ACS registry, currently been piloted in the Midland region, collects information on management and in-hospital outcomes. We report our initial experience with AC...
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J. Mazhar,
B. Killion,
M. Mitchell,
I. Ternouth,
M. Lee,
A. Kerr,
G. Devlin
et al.
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S24
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ALT—An Independent Marker of Coronary Artery Disease
Background: The cluster of cardiovascular risk factors known as the Metabolic Syndrome (MetS) is strongly associated with non-alcoholic fatty liver disease (NAFLD). NAFLD is also associated with eleva...
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Y. Tsai,
C. Ngan,
D. Palasubramaniam,
A. Wilson-O’Brien,
J. Layland,
R. Whitbourn,
A. Wilson
et al.
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S24
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