Remote ischemic preconditionining (IPC) has been defined as a brief episode of ischemia/reperfusion
in an organ that protects another remote organ from the damage induced by subsequent
and prolonged ischemia. As yet, no study has been conducted with the purpose of elucidating
a precise association between remote IPC and patterns of gene-transcription in cardiac
tissue. In this study, using a cDNA microarray, we analyzed the gene expression profile
in murine heart at 24 h after brief cycles of occlusion of the superior mesenteric artery. The profile revealed
that IPC induces significant levels of expression of many genes known to be associated
with the stress response, redox regulation, growth and metabolism, DNA repair and
other functions. The result of cDNA microarray profile from heart was also compared
with those from other organs (lung, kidney and intestine). The genes identified in
the expression profile may be associated with remote IPC induced late phase organ
protection.
Keywords
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© 2004 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
