Heart, Lung and Circulation
Abstract| Volume 17, SUPPLEMENT 1, S10, 2008

Hydrogen peroxide-induced apoptosis of neonatal rat cardiomyocyte was attenuated by a new active magnolol compound, CH-6784

      Background and objective: Recent study suggests that all active Magnolia constituents including magnolol, honokiol and CH-6784 decrease the reactive oxygen species in mammalian cell, which are essential for the biologic and physiologic cell function. In the cardiomyocytes (CMCs), the role of CH-6784 was not known. We assessed the hypothesis that CH-6784 reduces the hydrogen peroxide-induced apoptosis of neonatal rat CMCs by upregulation of redox-regulating thioredoxin (Trx) system.
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