Heart, Lung and Circulation
Abstract| Volume 17, SUPPLEMENT 1, S20, 2008

Catechin improves endothelial dysfunction by reducing NADPH oxidase activity in prediabetic stage of type 2 diabetic rat model

      Background: In the prediabetic stage, hyperinsulinemia or insulin resistance is thought to be closely associated with oxidative stress. An excess formation of reactive oxygen species (ROS) impairs endothelial function. Tea catechin inhibits NADPH oxidase activation and increases the protective effect of endothelial cells on the arterial wall by stimulating the endothelial formation of nitric oxide. The aim of this study was to investigate whether catechin could improve endothelial dysfunction and prevent hyperglycemia, hyperinsulinemia and blood pressure elevation in type 2 diabetic rat model.
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