I read with great interest the recent article by Campbell et al about aliskiren [
[1]
]. The authors have clearly shown that aliskiren increases tissue kallikrein expression
and bradykinin levels in the heart. Interestingly, other aliskiren has significant
direct cardio-protective effects in patients with significant cardio-thoracic pathologies.To read this article in full you will need to make a payment
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References
- Aliskiren increases tissue kallikrein expression and bradykinin levels in the heart.Heart, Lung and Circulation. 2008; 17: S1
- Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.Circulation: Heart Failure. 2008; 1: 17
- Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats.Hypertension. 2005; 46: 569-576
- Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat.Am J Physiol Endocrinol Metab. 2008; 295: E103-E109
- Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats.Hypertension. 2008; 52: 130-136
- AVOID Study Investigators. Aliskiren combined with losartan in type 2 diabetes and nephropathy.N Engl J Med. 2008; 358: 2433-2446
- Effects of aliskiren, a direct renin inhibitor, on cardiac repolarization and conduction in healthy subjects.J Clin Pharmacol. 2008; 48: 799-811
- 76: Aliskiren: a new anti-renin blood pressure medication appears safe and effective in heart transplant recipients.Journal of Heart and Lung Transplantation. 2008; 27: 86-87
- Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine.Hypertension. 2008; 51: 1306-1311
- Aliskiren as an alternative in a patient with life-threatening ACE inhibitor-induced angioedema.Am J Kidney Dis. 2008; 51: 532-533
Article info
Publication history
Received:
July 17,
2008
Identification
Copyright
© 2008 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
