Heart, Lung and Circulation
Letter to the Editor| Volume 18, ISSUE 5, P372, October 2009

Aliskiren and Its Rapidly, Evolving Role in the Management of Cardio-Thoracic Diseases

      I read with great interest the recent article by Campbell et al about aliskiren [
      • Campbell D.
      • Zhang Y.
      • Kelly D.
      • Gilbert R.
      Aliskiren increases tissue kallikrein expression and bradykinin levels in the heart.
      ]. The authors have clearly shown that aliskiren increases tissue kallikrein expression and bradykinin levels in the heart. Interestingly, other aliskiren has significant direct cardio-protective effects in patients with significant cardio-thoracic pathologies.
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        • Zhang Y.
        • Kelly D.
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        Aliskiren increases tissue kallikrein expression and bradykinin levels in the heart.
        Heart, Lung and Circulation. 2008; 17: S1
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        Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine.
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        Aliskiren as an alternative in a patient with life-threatening ACE inhibitor-induced angioedema.
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