Advertisement
Heart, Lung and Circulation
Case Report| Volume 18, ISSUE 5, P367-369, October 2009

Can β Agonists Cause Dilated Cardiomyopathy?

      We report a case of dilated cardiomyopathy that we believe is secondary to excessive use of inhaled β agonists. Clinicians should be mindful of this possibility when using β agonists to treat patients with obstructive airways disease; particularly if there is already recognised left ventricular dysfunction.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Heart, Lung and Circulation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Richardson P.
        • McKenna W.
        • Bristow M.
        • Maisch B.
        • Mautner B.
        • O’Connell J.
        • Olsen E.
        • Thiene G.
        • Goodwin J.
        • Gyarfas I.
        • Martin I.
        • Nordet P.
        Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies.
        Circulation. 1996; 93: 841-842
        • Salpeter S.R.
        • Ormiston T.M.
        • Salpeter E.E.
        Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis.
        Chest. 2004; 125: 2309-2321
        • Au D.H.
        • Udris E.M.
        • Fan V.S.
        • Curtis J.R.
        • McDonell M.B.
        • Fihn S.D.
        Risk of mortality and heart failure exacerbations associated with inhaled beta-adrenoceptor agonists among patients with known left ventricular systolic dysfunction.
        Chest. 2003; 123: 1964-1969
        • Coughlin S.S.
        • Metayer C.
        • McCarthy E.P.
        • Mather F.J.
        • Waldhorn R.E.
        • Gersh B.J.
        • DuPraw S.
        • Baughman K.L.
        Respiratory illness, beta-agonists, and risk of idiopathic dilated cardiomyopathy. The Washington, DC, Dilated Cardiomyopathy Study.
        Am J Epidemiol. 1995; 142: 395-403
        • Stewart M.J.
        • Fraser D.M.
        • Boon N.
        Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.
        Br Heart J. 1992; 68: 221-222
        • Sardesai S.H.
        • Mourant A.J.
        • Sivathandon Y.
        • Farrow R.
        • Gibbons D.O.
        Phaeochromocytoma and catecholamine induced cardiomyopathy presenting as heart failure.
        Br Heart J. 1990; 63: 234-237
        • Fripp R.R.
        • Lee J.C.
        • Downing S.E.
        Inotropic responsiveness of the heart in catecholamine cardiomyopathy.
        Am Heart J. 1981; 101: 17-21
        • Wilkenfeld C.
        • Cohen M.
        • Lansman S.L.
        • Courtney M.
        • Dische M.R.
        • Pertsemlidis D.
        • Krakoff L.R.
        Heart transplantation for end-stage cardiomyopathy caused by an occult pheochromocytoma.
        J Heart Lung Transplant. 1992; 11: 363-366
        • Neil-Dwyer G.
        • Walter P.
        • Cruickshank J.M.
        • Doshi B.
        • O’Gorman P.
        Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.
        Br Med J. 1978; 2: 990-992
        • Wittstein I.S.
        • Thiemann D.R.
        • Lima J.A.
        • Baughman K.L.
        • Schulman S.P.
        • Gerstenblith G.
        • Wu K.C.
        • Rade J.J.
        • Bivalacqua T.J.
        • Champion H.C.
        Neurohumoral features of myocardial stunning due to sudden emotional stress.
        N Engl J Med. 2005; 352: 539-548