Background
Conventional risk factors for coronary heart disease (CHD) and ischaemic stroke (IS)
have been well documented. This study examines whether there is a unique pattern of
risk factors for each disease.
Methods
This is a prospective cohort study in Dubbo NSW which has followed 2805 men and women
60 years and older for 16 years since 1988–1989. CHD and IS events were identified
by hospital record linkage. The independent contributions of risk factors to these
events were evaluated in proportional hazards regression models.
Results
CHD events (without stroke) occurred in 853 subjects (30.4/100). IS events (without
CHD) occurred in 185 subjects (6.6/100). Some risk factors produced broadly similar
prediction of CHD and IS events (male sex, current smoking, diabetes, LDL cholesterol,
reduced peak expiratory flow, physical disability). Other factors potentially produced
unique prediction of CHD (CHD at baseline, family history of CHD, HDL cholesterol,
ApoB/ApoA1 ratio) or IS (stroke at baseline), or stronger prediction of IS compared
with CHD (age, hypertension, atrial fibrillation).
Conclusions
CHD and IS may each have some unique predictors, but treatable risk factors have been
demonstrated for both cardiovascular outcomes.
Keywords
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Article info
Publication history
Accepted:
May 6,
2009
Received in revised form:
May 4,
2009
Received:
December 24,
2008
Identification
Copyright
© 2009 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
