Background
We compared the prognostic power of three pharmacological stress echocardiography
protocols for predicting improvement of global left ventricular systolic function
following revascularisation.
Methods
We enrolled 100 consecutive patients with significant coronary stenosis/occlusion
and regional dys-synergy in the affected artery territory. Patients underwent assessment
of regional and global left ventricular systolic function. They underwent then three
pharmacological stress echocardiography protocols: low dose dobutamine, infra-low
dose dipyridamole, combined protocol. All patients underwent coronary revascularisation.
Echocardiography was repeated 8 weeks later. Predicted function improvement by the
three protocols was compared with actual improvement.
Results
The combined protocol was more sensitive to predict systolic function improvement
after revascularisation, but less specific, the diagnostic accuracy was similar among
the three protocols. A cutoff value of 6 viable segments best predicted global function
improvement with the combined protocol.
Conclusions
The combined protocol has a higher sensitivity but lower specificity to predict global
left ventricular systolic function improvement after revascularisation, as compared
to the other two protocols.
Keywords
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Article info
Publication history
Accepted:
August 17,
2009
Received in revised form:
June 20,
2009
Received:
February 7,
2009
Identification
Copyright
© 2009 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
