Background
Tako-tsubo cardiomyopathy is an increasingly recognised phenomenon characterised by
chest pain, ECG abnormalities, cardiac biomarker elevation and transient left ventricular
dysfunction without significant coronary artery obstruction.
Aims
To report the clinical and echocardiographic characteristics from a large single-centre
Australian series of patients with Tako-tsubo syndrome.
Methods
We prospectively collected data on 23 consecutive patients presenting between November
2005 and November 2007. Baseline demographics, ECG, echocardiography and coronary
angiography were performed on nearly all patients.
Results
All patients presented with chest pain; 87% were female. Various stressors were noted
and cardiac Troponin-T was elevated in 91% of patients. All patients had non-obstructive
coronary disease at angiography. 19/23 patients had initial and subsequent echocardiography.
Mean ejection fraction was 50% at baseline and 64% at follow-up (p < 0.0001). Right ventricular dysfunction was present in eight, dynamic left ventricular
outflow tract obstruction in two, diastolic dysfunction in seven and two patients
had the mid-cavity variant.
Conclusions
This large prospective single-centre Australian series of Tako-tsubo syndrome is in
concert with previous published series. Complete recovery of left ventricular function
on echocardiographic follow-up was typical. Although its pathogenesis remains unclear,
early distinction from acute coronary syndromes is important and the prognosis is
reassuringly good.
Keywords
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Article info
Publication history
Accepted:
October 10,
2009
Received in revised form:
October 6,
2009
Received:
March 21,
2009
Identification
Copyright
© 2009 Published by Elsevier Inc. All rights reserved.
