Background
Cardiac isoform of alpha 2 macroglobulin (CA2M), a serum protein (182000Mr) has been
used as a diagnostic molecular marker for cardiac manifestations in HIV and diabetic
patients. This study investigates the reliability of CA2M as an early diagnostic marker
for cardiac manifestations in HIV patients and factors that could possibly influence
their levels.
Methods
A total of 206 serum samples were analysed from HIV patients with cardiac diseases
(68), with non-cardiac ailments (48), opportunistic infections (34) and without other
co-morbidities (56). The immuno-cross-reactivity between human serum CA2M and anti-rat
CA2M antibody was tested and quantified by sandwich enzyme linked immunosorbent assay
(ELISA).
Results
The CA2M levels were high in HIV patients with cardiac diseases irrespective of the
manifestations. The CA2M levels were not influenced by opportunistic infections, non-cardiac
ailments and patient parameters like age, sex, duration of illness, past history of
other co-morbidities.
Conclusion
CA2M can be used as a reliable early diagnostic marker in HIV patients with cardiac
manifestations. CA2M levels were not influenced by other patient parameters.
Keywords
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Article info
Publication history
Accepted:
October 19,
2009
Received in revised form:
October 19,
2009
Received:
July 19,
2009
Identification
Copyright
© 2009 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
