It has been known for two decades that cardiopulmonary bypass for coronary artery grafting is associated with significant oxidative stress upon the heart [
] and off-pump surgery appears to reduce this stress [
- Ferrari R.
- Alfieri O.
- Curello S.
- Ceconi C.
- Cargnoni A.
- Marzollo P.
- et al.
Occurrence of oxidative stress during reperfusion of the human heart.
Circulation. 1990; 81: 201-211
]. In the paediatric population, oxidative stress during cardiopulmonary bypass has also been reported as a possible contributor to post-operative complications [
- Matata B.M.
- Sosnowski A.W.
- Galinanes M.
Off-pump bypass graft operation significantly reduces oxidative stress and inflammation.
Annals Thoracic Surgery. 2000; 69: 785-791
]. Currently, however, cardiopulmonary bypass remains the standard support for coronary surgery and is fundamental for valve and aortic surgery.
- Christen S.
- Finckh B.
- Lykkesfeldt J.
- Gessler P.
- Frese-Schaper M.
- Nielsen P.
- et al.
Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.
Free Radical Biology Medicine. 2005; 38: 1323-1332
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- Occurrence of oxidative stress during reperfusion of the human heart.Circulation. 1990; 81: 201-211
- Off-pump bypass graft operation significantly reduces oxidative stress and inflammation.Annals Thoracic Surgery. 2000; 69: 785-791
- Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.Free Radical Biology Medicine. 2005; 38: 1323-1332
- The role of oxidants and free radicals in reperfusion injury.Cardiovascular Research. 2006; 70: 181-190
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- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting.Annals Thoracic Surgery. 1994; 58: 1427-1432
- Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations.Annals Thoracic Surgery. 1996; 61: 829-833
- Myocardial ischemia–reperfusion injury, antioxidant systems and selenium: a review.Current Medicinal Chemistry. 2007; 14: 1539-1549
- The impact of cardiopulmonary bypass on selenium status, thyroid function and oxidative defense in children.Pediatric Cardiology. 2004; 25: 522-528
© 2010 Published by Elsevier Inc.