It has been known for two decades that cardiopulmonary bypass for coronary artery
grafting is associated with significant oxidative stress upon the heart [
[1]
] and off-pump surgery appears to reduce this stress [
[2]
]. In the paediatric population, oxidative stress during cardiopulmonary bypass has
also been reported as a possible contributor to post-operative complications [
[3]
]. Currently, however, cardiopulmonary bypass remains the standard support for coronary
surgery and is fundamental for valve and aortic surgery.To read this article in full you will need to make a payment
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References
- Occurrence of oxidative stress during reperfusion of the human heart.Circulation. 1990; 81: 201-211
- Off-pump bypass graft operation significantly reduces oxidative stress and inflammation.Annals Thoracic Surgery. 2000; 69: 785-791
- Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.Free Radical Biology Medicine. 2005; 38: 1323-1332
- The role of oxidants and free radicals in reperfusion injury.Cardiovascular Research. 2006; 70: 181-190
- N-Acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind placebo-controlled trial.Journal Thoracic Cardiovascular Surgery. 2003; 126: 1513-1520
- Influence of intravenous Vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study.British Journal Anaesthesia. 2003; 90: 148-154
- Strategies to reduce oxidative stress in cardiovascular disease.Clinical Science. 2004; 106: 219-234
- Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomized trial.Heart Lung and Circulation. 2010; 19: 584-591
- Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting.Annals Thoracic Surgery. 1994; 58: 1427-1432
- Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations.Annals Thoracic Surgery. 1996; 61: 829-833
- Myocardial ischemia–reperfusion injury, antioxidant systems and selenium: a review.Current Medicinal Chemistry. 2007; 14: 1539-1549
- The impact of cardiopulmonary bypass on selenium status, thyroid function and oxidative defense in children.Pediatric Cardiology. 2004; 25: 522-528
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© 2010 Published by Elsevier Inc.
