Heart, Lung and Circulation
Young Achievers Award| Volume 20, ISSUE 4, P250, April 2011

Poly-unsaturated Fatty Acid Composition of Epicardial Adipose Tissue in Coronary Artery Disease (CAD) Patients and Controls: Design and Feasibility

      Introduction: Beneficial effects of omega-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) on cardiac muscle are secondary to their membrane stabilisation effect due to antioxidative properties and antiartherogenic effect due to its anti-inflammatory properties. We sought to determine whether: (1) there was a preferential accumulation of omega-3 in epicardial adipose tissue; (2) epicardial adipose tissue was different in its composition compared to other sources of adipose in the body; (3) a difference existed in the expression of lipid-specific genes between different sources of adipose within the body; and (4) a difference in the adipose composition in patients with and without CAD.
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