Heart, Lung and Circulation
Abstract| Volume 20, ISSUE 4, P257-258, April 2011

Is Home Warfarin Self Management Effective? Results and Implications of the Warfarin S.M.A.R.T. Study

      Introduction: The Warfarin Self-Management Anti-coagulation Research Trial (Warfarin SMART) was designed to determine whether patients self-managing warfarin (PSM) using the CoaguChek device and a dosing algorithm developed for the trial, could keep INR in target range at least as often as patients managed by usual care (UC) by the family doctor or hospital clinic. Most previous trials and meta-analyses about patient self-management unfairly favour the device and self management or contain other biases in the design. The Warfarin SMART study was adequately powered to rule out PSM being inferior to UC by up to a 6% higher rate of out-of-range INRs in an unbiased design.
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