The metabolic syndrome (MetS), comprising the cardiovascular risk factors of obesity, hypertension, diabetes, elevated plasma triglycerides and low high-density cholesterol, is now well-recognised as being associated with increased risk of cardiovascular disease. The question arises, however, of whether or not the constellation of factors, defined as the MetS confers a specific increase in cardiovascular risk, beyond that conferred by the individual risk factors themselves. This question is not merely academic, as if the MetS did confer additional risk, then we may well wish to be more aggressive about treatment of individual factors in patients with the MetS, and of course wish to identify the specific risk-factor interactions responsible for the incremental risk associated with MetS. It is this question, which is addressed by Simons et al. in their paper in the current issue of the journal [
- Simons L.A.
- Simons J.
- Friedlander Y.
- McCallum J.
Is prediction of cardiovascular disease and all-cause mortality genuinely driven by the metabolic syndrome, and independently from its component variables? The Dubbo Study.
Heart Lung Circulation. 2011; 20: 214-219
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- Is prediction of cardiovascular disease and all-cause mortality genuinely driven by the metabolic syndrome, and independently from its component variables? The Dubbo Study.Heart Lung Circulation. 2011; 20: 214-219
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© 2011 Published by Elsevier Inc.