Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being
precipitated in many cases by severe emotional stress. We describe six patients in
whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/noradrenaline
reuptake inhibitor venlafaxine, or its metabolite desvenlafaxine. Importantly, two
of the six cases were not post-menopausal women. An increased risk of TTC may account
for some of the reported cardiovascular adverse effects of venlafaxine and similar
agents.
Keywords
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References
- Clinical correlates and prognostic significance of electrocardiographic abnormalities in apical ballooning syndrome (Takotsubo/stress-induced cardiomyopathy).Am Heart J. 2009; 157: 933-938
- Incidence, clinical findings, and outcome of women with left ventricular apical ballooning syndrome.Am J Cardiol. 2007; 99: 182-185
- Takotsubo-type cardiomyopathy due to multivessel spasm.in: Kodama K. Haze K. Hon M. Clinical aspect of myocardial injury from ischemia to heart failure. Kagakuhyouronsha, Tokyo1990: 56-64
- Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction.Ann Intern Med. 2004; 141: 858-865
- Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review.Eur Heart J. 2006; 27: 1523-1529
- Mechanisms of stress (Takotsubo) cardiomyopathy.Nat Rev Cardiol. 2010; 7: 187-193
- Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy.J Am Coll Cardiol. 2010; 55: 333-341
- Neurohumoral features of myocardial stunning due to sudden emotional stress.N Engl J Med. 2005; 352: 539-548
- A new variant of Tako-tsubo cardiomyopathy: transient mid-ventricular ballooning.J Cardiovasc Med (Hagerstown). 2007; 8: 1052-1054
- “Inverted Takotsubo” pattern.Resuscitation. 2007; 74: 394
- Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes?.J Electrocardiol. 2009; 42 (e1): 353-357
- Four-year recurrence rate and prognosis of the apical ballooning syndrome.J Am Coll Cardiol. 2007; 50: 448-452
- Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles.Circulation. 2004; 109: 3202-3207
- A case of apical ballooning cardiomyopathy associated with duloxetine.Ann Intern Med. 2008; 149: 218-219
- Broken heart syndrome: Tako Tsubo cardiomyopathy associated with an overdose of the serotonin-norepinephrine reuptake inhibitor Venlafaxine.Eur Neuropsychopharmacol. 2010; 20: 594-597
- An unusual case of mid-ventricular Takotsubo cardiomyopathy.QJM. 2010; 103: 695-696
- N-terminal pro-brain natriuretic protein levels in takotsubo cardiomyopathy.Am J Cardiol. 2011; 108: 1316-1321
- Long QT syndrome and torsade de pointes in transient left ventricular apical ballooning syndrome.Int J Cardiol. 2005; 100: 499-501
- Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists.J Am Coll Cardiol. 2009; 53: 1320-1325
- Takotsubo-like cardiomyopathy in pheochromocytoma.Int J Cardiol. 2011;
- Acute heart failure associated with venlafaxine poisoning.Am J Emerg Med. 2007; 25: 210-211
- “Tako-tsubo” cardiomyopathy and duloxetine use.South Med J. 2011; 104: 345-347
- Venlafaxine induced acute myocardial infarction with normal coronary arteries.Am J Ther. 2009; 16: 365-366
- Duloxetine-associated tachycardia.Ann Pharmacother. 2008; 42: 1511-1513
- Heart failure worsening and exacerbation after venlafaxine and duloxetine therapy.Ann Pharmacother. 2008; 42: 882-887
- Fatal cardiotoxicity induced by venlafaxine overdosage.Clin Toxicol (Phila). 2008; 46: 336-337
Article info
Publication history
Accepted:
December 19,
2011
Received in revised form:
November 30,
2011
Received:
July 11,
2011
Identification
Copyright
© 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.
