Introduction
Pulmonary metastases are relatively common after definitive treatment for sarcoma
of soft tissue and bone. Minimal data exists on outcomes following pulmonary metastasectomy
for sarcoma of gynaecologic origin (SOGO). A retrospective study was performed to
compare overall outcomes of pulmonary metastasectomy for SOGO.
Methods
Patients selected had control of their primary tumour, no extra-thoracic disease and
were declared fit for surgery. The primary aim was to determine long-term outcomes
following pulmonary metastasectomies in patients with sarcoma of gynaecological origin.
The International Registry of Lung Metastases (IRLM) staging system, resection status
and surgical approach were documented.
Results
Of 101 patients who underwent sarcoma pulmonary metastasectomy between the 2001 and
2011, 13 patients had SOGO (12 leiomyosarcoma). The median age for those undergoing
resection for SOGO was 58.2 years. Four patients required iterative metastasectomy.
Median OS for SOGO was 76.4 months (95% CI: 11.8–141.0). The three- and five-year
survival for sarcoma of gynaecologic origin was 76% and 66% respectively. For all
sarcoma cases, minimally invasive surgery was shown to confer a significant survival
benefit; five-year OS was 67% compared to 38% for open surgery (p = 0.04).
Discussion
Outcomes after pulmonary metastasectomy for SOGO are favourable compared to other
sarcoma resection. IRLM staging was a good predictor of patient outcome. Minimally
invasive surgery may have oncologically equivalent outcomes compared to open surgery.
Keywords
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Article info
Publication history
Published online: December 26, 2012
Accepted:
November 1,
2012
Received in revised form:
October 26,
2012
Received:
July 23,
2012
Identification
Copyright
© 2012 Published by Elsevier Inc. All rights reserved.
