Background
Iron deficiency has been reported to be highly prevalent in idiopathic pulmonary arterial
hypertension (iPAH) patients, with the potential to influence cardiac performance,
pulmonary artery pressures and the pulmonary vascular response to hypoxia.
Methods
Iron status was evaluated in 29 iPAH patients, and was related to haemodynamic, echocardiographic
and exercise parameters.
Results
Iron deficiency was present in 44.8% of all iPAH patients, although anaemia was only
present in 13.8%. Iron-deficient patients had similar exercise capacity (6MWD: 446 ± 141 m), compared to iron-sufficient patients (421 ± 193 m), however 46.2% of iron deficient patients had NYHA FC 3 or higher, compared to
12.5% in non-iron deficient group. Additionally iron-deficient patients showed increased
mean pulmonary arterial pressure (63.3 ± 12.2 mmHg; iron deficient vs. 38.8 ± 16.7 mmHg; non-iron deficient) and reduced cardiac index (1.3 ± 0.2 L/min/m2; iron deficient vs. 2.5 ± 0.4 L/min/m2; non-iron deficient).
Conclusions
Iron deficiency is highly prevalent in iPAH, and the extent of iron deficiency is
related to haemodynamics and NYHA functional class. While the exact mechanism of iron
deficiency is unknown, our study suggests that treatment of iron deficiency should
be considered in iPAH patients.
Keywords
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Article info
Publication history
Published online: October 03, 2013
Accepted:
August 17,
2013
Received in revised form:
July 17,
2013
Received:
May 18,
2013
Identification
Copyright
© 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.
