Background
In South Africa respiratory diseases are highly prevalent, with cardiovascular disease
being a manifestation. However, international reference values for lung function are
commonly used, which may not be appropriate to correctly identify reduced lung function.
An inverse relationship exists between lung function and blood pressure (BP) but is
not investigated extensively in black South Africans.
Methods
We included 2010 Africans from the PURE (Prospective Urban Rural Epidemiology) study
(aged > 35 years) in the North West Province. Spirometry was performed and predicted
values for forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated from South African, European and
United States prediction equations.
Results
With the exception of the European predicted values, all other predicted mean FEV1 and FVC were above 80%. South African reference values displayed the highest percentages
of the predicted values for FEV1 and FVC (87.9 and 99.7%, respectively.) BP increased from quintiles five to one for
both FEV1 and FVC, (p for trend <0.001). After adjustment the differences remained (p<0.05).
Conclusions
South African reference values yielded higher percentages of predicted FEV1 and FVC values than European and US equations suggesting that South African prediction
equations may be more useful when investigating lung function in black South Africans.
Elevated BP is related to reduced lung function, highlighting the importance in managing
both respiratory- and cardiovascular disease.
Keywords
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Article info
Publication history
Published online: December 27, 2014
Accepted:
December 2,
2014
Received:
August 27,
2014
Identification
Copyright
© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.
