Background
Although both chronic obstructive pulmonary disease (COPD) and cardiovascular diseases
(CVD) are characterised by chronic, systemic inflammation, their reciprocal interactions
are poorly understood. The purpose of this study was to determine the concentrations
of both inflammatory and oxidative stress biomarkers in the serum and exhaled breath
condensate (EBC) of COPD patients, either with coexisting CVD or without cardio-vascular
comorbidities.
Methods
Twenty-four COPD patients with CVD were allocated to group A, 20 COPD patients without
CVD were assigned to group B and 16 healthy patients were included as a control. A
medical history and physical examination were performed, and the following were measured:
serum CRP concentration, glucose level, uraemic acid level and lipid profile. In addition
8-isoprostane, LTB4 and IL-8 concentrations were measured both in serum and EBC. Spirometry,
six-minute walk test and echocardiography were performed in all subjects.
Results
EBC concentrations of 8-isoprostane and LTB4, and serum levels of CRP, 8-soprostane,
LTB4, IL-8 were significantly higher in COPD patients than in healthy controls. COPD
patients with CVD were not found to have higher concentrations of the assessed markers
than those without CVD, neither in the serum nor EBC. CRP, 8-isoprostane and LTB4
levels in serum, and IL-8 concentration in EBC correlated negatively with the value
of forced expiratory volume in one second.
Conclusions
Although systemic inflammation coexists with COPD, it is not elevated in COPD patients
with CVD. Since this phenomenon may result from treatment with statins, future studies
should state whether COPD patients could benefit from the additional statin therapy.
Keywords
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Article info
Publication history
Published online: February 20, 2015
Accepted:
January 29,
2015
Received in revised form:
January 27,
2015
Received:
March 29,
2014
Identification
Copyright
© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.
