Background
The study aimed to explore possible factors influencing wheezing in children with
Mycoplasma pneumoniae pneumonia (MPP).
Methods
The study included 84 children with MPP, who were divided into two groups: wheezy
group (n = 40) and non-wheezy group (n = 44), along with 30 age-matched healthy controls. T-cell immunoglobulin and mucin domain
gene (Tim) 1, 3 and Toll-like receptor (TLR) 2, 4 were evaluated using RT-PCR. Serum
IL-10, TNF-α, IFN-γ and IgE were assessed by enzyme-linked immunosorbent assay. Peripheral
blood eosinophil (EOS) was measured by an automated haematology.
Results
Children with MPP had markedly increased TLR2, TLR4, Tim1, IL-10, TNF-α, IgE and EOS,
and decreased IFN-γ than the healthy controls. In the presence of MPP, wheezy children
had significantly elevated TLR2, Tim1, Tim3, TNF-α, IgE and EOS than non-wheezy children.
In wheezy children with MPP, MP-specific antibody titre was positively correlated with
TLR2 and TIM1, and negatively correlated with IFN-γ. IgE was positively correlated
with TLR2, TLR4 and Tim1, while EOS was positively correlated with Tim1 and Tim3.
Conclusion
TLR2, Tim1, Tim3, TNF-α, IgE and EOS play a role in MPP-related wheezing in children.
The role of IgE might be associated with TLR2 and Tim1, and the role of EOS might
be associated with Tim1 and Tim3.
Keywords
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Article info
Publication history
Published online: April 29, 2016
Accepted:
March 28,
2016
Received in revised form:
March 3,
2016
Received:
January 22,
2016
Identification
Copyright
© 2016 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
