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Heart, Lung and Circulation

Cardiac-Specific Insulin-like Growth Factor-1 Receptor (IGF-1R) Expression Attenuates Upregulation of Left Ventricular Hexosamine Biosynthesis (HBP) Flux and Oxidative Stress in Diabetic Mouse Myocardium

      Tabled 1
      Results: mean ± SEMNtgIGF1R Tg
      CIT (n=13)STZ (n=10)CIT (n=16)STZ (n=16)
      Body weight (g)32.8±0.9831.9±1.035.4±1.230.7±0.7*
      Endpoint glucose (mM)11.8±0.331.2±0.9*11.1±0.531.1±0.7*ζ
      HbA1c (%)3.91±0.159.07±0.19*4.09±0.118.14±0.34*ζ
      E/A ratio1.98±0.141.34±0.09*2.34±0.262.01±0.25ζ
      Superoxide generation1.00±0.163.25±0.98*1.39±0.271.65±0.38ζ
      Nox2 gene expression1.00±0.153.84±1.53*0.77±0.140.95±0.13ζ
      Total 3-nitrotyrosine protein1.00±0.081.52±0.10*0.73±0.070.74±0.05ζ
      Collagen deposition (au)3.27±0.428.77±0.89*4.02±0.585.88±0.64ζ
      Total O-GlcNAc protein1.00±0.091.69±0.17*0.71±0.050.76±0.07ζ
      Total SERCA2a protein1.00±0.070.66±0.08*1.14±0.111.13±0.12ζ
      O-GlcNAc-SERCA2a protein1.00±0.112.52±0.56*1.05±0.151.14±0.18ζ
      *P<0.05 CIT vs STZ within genotype; ζP<0.05 STZ between genotypes