Heart failure (HF) is a major health care burden associated with high morbidity and
mortality. Approximately 50% of HF patients have reduced ejection fraction (HFrEF)
while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark
of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary
to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training
is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date
suggests that the mechanism of this improvement appears to be related to underlying
HF phenotype. The purpose of this review is to discuss the role of exercise training
to improve VO2peak, and how the central and peripheral adaptations that mediate the improvements in
exercise tolerance may be similar or differ by HF phenotype (HFrEF or HFpEF).
Keywords
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Article info
Publication history
Published online: August 03, 2017
Accepted:
July 16,
2017
Received in revised form:
June 22,
2017
Received:
May 8,
2017
Identification
Copyright
© 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
