The aim of this study was to define the status of preoperative zinc levels in patients with heart disease presenting for cardiac surgery and to identify any predictors for and any clinical consequences of low zinc levels.
Adult patients presenting for elective surgery, either coronary artery bypass graft surgery and/or valve replacement, provided a fasting blood sample on the day of admission for surgery. Plasma and erythrocyte zinc levels were analysed and the levels correlated with the patient’s characteristics and clinical outcomes.
Of 56 patients 53% (n = 30) had abnormally low plasma zinc levels (<12 μmol/L) and 5.5% (n = 3) had abnormally low erythrocyte zinc levels (<160 μmol/L), indicative of deficiency. There were significant associations between lower plasma zinc levels and the presence of hypertension (p = 0.02), hypercholesteraemia (p = 0.02) and higher body mass index (BMI) (p = 0.034) but no effect on major postoperative clinical outcomes.
This small study shows that zinc deficiency is common in cardiac surgery patients, especially in the presence of hypertension, hypercholesterolaemia or obesity. The effects of zinc deficiency in cardiac surgery need to be further investigated.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Heart, Lung and Circulation
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Prognostic value of serum zinc levels in critically ill patients.J Crit Care. 2011; 26: 42-46
- Analysis of zinc in biological samples by flame atomic absorption spectrometry: use of addition calibration technique.Biol Trace Elem Res. 2006; 111: 265-279
- Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data.Am J Clin Nutr. 2003; 78: 756-764
- Comparison of direct versus indirect determination of zinc concentration in erythrocytes in euthyroid and hyperthyroid subjects.Eur J Clin Chem Clin Biochem. 1993; 31: 239-244
- The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults.Chest. 1991; 100: 1619-1636
- Zinc in Human Health: Effect of Zinc on Immune Cells.Mol Med. 2008; 14: 353-357
- Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress.Am J Clin Nutr. 2007; 85: 837-844
- Systemic Free Radical Activation Is a Major Event Involved In Myocardial Oxidative Stress Related to Cardiopulmonary Bypass.Anesthesiology. 2002; 96: 80-87
- Zinc and its importance for human health: An integrative review.J Res Med Sci. 2013; 18: 144-157
- Whole blood and serum zinc levels in relation to sex and age.Rev Esp Fisiol. 1985; 41: 463-470
- Serum zinc in critically ill adult patients with acute respiratory failure.Acta Anaesthesiol Scand. 2011; 55: 615-621
- Pharmaco-nutrient interactions: – a systematic review of zinc and antihypertensive therapy.Int J Clin Pract. 2013; 67: 717-725
- The effect of losartan and losartan/hydrochlorothiazide fixed-combination on magnesium, zinc, and nitric oxide metabolism in hypertensive patients: a prospective open-label study.Am J Hypertens. 2005; 18: 358-363
- Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study.Nutr Metab. 2012; 9: 59
Published online: August 14, 2017
Accepted: July 26, 2017
Received in revised form: June 22, 2017
Received: May 3, 2017
© 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.