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Brief Communication| Volume 27, ISSUE 6, P763-766, June 2018

Evaluation of Cobalt and Chromium Levels Following Implantation of Cobalt Chromium Coronary Stents: A Pilot Study

  • Pietro Di Santo
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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  • Pouya Motazedian
    Affiliations
    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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  • Richard G. Jung
    Affiliations
    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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  • Trevor Simard
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
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  • F. Daniel Ramirez
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada
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  • Aun-Yeong Chong
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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  • Christopher Glover
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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  • Benjamin Hibbert
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
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  • Girish Dwivedi
    Correspondence
    Corresponding author at: Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, WA 6009, Australia. Tel.: +61 0861510000.
    Affiliations
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Harry Perkins Institute of Medical Research, Nedlands, WA, Australia
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Published:December 14, 2017DOI:https://doi.org/10.1016/j.hlc.2017.12.002
Evaluation of Cobalt and Chromium Levels Following Implantation of Cobalt Chromium Coronary Stents: A Pilot Study
Previous ArticlePrevalence of Zinc Deficiency in Cardiac Surgery Patients
Next ArticleAortic Cannulation in DeBakey Type I Aortic Dissection Facilitates Subsequent Deployment of a Frozen Elephant Trunk

      Background

      Large increases in myocardial trace elements may adversely affect metabolism and become detrimental to cardiac function. Percutaneous coronary intervention (PCI) allows for the revascularisation of obstructive coronary artery disease using drug-eluting stents. These stents are comprised of a metallic stent backbone covered in an engineered polymer which delivers a drug over a prescribed period to the vessel wall. Given the potential implications of trace metal accumulation within the myocardium, our goal is to determine if metallic coronary stents are able to cause detectable elevations in serum cobalt and/or chromium levels.

      Methods

      This study was a single centre, observational, pilot study with 20 patients who underwent planned PCI with implantation of a cobalt chromium drug eluting stent. Serum blood samples were drawn at baseline prior to PCI, 4 hours post-stent deployment and at the time of routine follow-up after PCI. All blood samples were analysed for cobalt and chromium concentrations. The primary outcome of this study was the difference in serum cobalt and chromium levels at routine clinical follow-up.

      Results

      The mean follow up was 64.1 ± 17.3 days. There was no difference in serum cobalt levels when comparing baseline and routine clinical follow up (3.32 ± 2.14 nmol/L vs. 3.14 ± 1.00 nmol/L, p = 0.99) nor in chromium levels (4.24 ± 2.31 nmol/L vs. 2.82 ± 1.22 nmol/L, p = 0.11). There was also no difference between baseline and 4 hours post-PCI serum concentrations.

      Conclusions

      Percutaneous coronary intervention with cobalt chromium coronary stents does not appear to cause an elevation in these trace element serum concentrations.

      Keywords

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      Article info

      Publication history

      Published online: December 14, 2017
      Accepted: December 3, 2017
      Received: May 27, 2017

      Identification

      DOI: https://doi.org/10.1016/j.hlc.2017.12.002

      Copyright

      © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

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