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Heart, Lung and Circulation

Daily Step Count as a Simple Marker of Disease Severity in Hypertrophic Cardiomyopathy

  • Joanna Sweeting
    Affiliations
    Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, NSW, Australia

    Sydney Medical School, University of Sydney, Sydney, NSW, Australia
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  • Jodie Ingles
    Affiliations
    Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, NSW, Australia

    Sydney Medical School, University of Sydney, Sydney, NSW, Australia

    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
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  • Kylie Ball
    Affiliations
    Centre for Physical Activity and Nutrition Research, Deakin University, Melbourne, Vic, Australia
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  • Christopher Semsarian
    Correspondence
    Corresponding author at: Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Locked Bag 6, Newtown, NSW 2042, Australia.
    Affiliations
    Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney, NSW, Australia

    Sydney Medical School, University of Sydney, Sydney, NSW, Australia

    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Search for articles by this author
Published:January 27, 2018DOI:https://doi.org/10.1016/j.hlc.2017.12.012

      Background

      Individuals with hypertrophic cardiomyopathy (HCM) may be asymptomatic or display activity-limiting symptoms. A common cause of symptoms is left ventricular outflow tract obstruction (LVOTO), which may impact the individuals’ ability to undertake physical activity. This study sought to examine daily step count as a potential marker of exercise capacity, which may represent a proxy marker of disease severity in HCM.

      Methods

      A cross-sectional study of 63 HCM patients was conducted from March to November 2015. Participants wore an ActiGraph GT3X+ (Pensacola, Florida, USA) accelerometer for 7 days. Minutes per day of light, moderate and vigorous physical activity and step count were calculated, and those with LVOTO were compared to those without. Similarly, those with good functional capacity (New York Heart Association; NYHA class I) were compared to those with NYHA class II–IV.

      Results

      The majority of HCM patients were male (n = 45, 71%) with mean age of 48.8 ± 14.9 years. Hypertrophic cardiomyopathy patients with history of LVOTO and those NYHA class II–IV took significantly fewer steps per day (LV obstruction: 5527 ± 2370 versus 7027 ± 2095, p = 0.01 and NYHA: 5346 ± 1898 versus 6801 ± 2339, p = 0.03). No differences were observed across the different intensities of physical activity.

      Conclusions

      Measurement of daily step count may be a useful and simple tool to determine exercise capacity and provide an indicator of disease severity in individuals with HCM.

      Keywords

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