Background
Data on the effects of transcatheter aortic valve replacement (TAVR) compared to surgical
aortic valve replacement (SAVR) on health-related quality of life (HRQOL) outcomes
are limited. To assess the comparative HRQOL outcomes between TAVR and SAVR, we performed
a systematic review and meta-analysis.
Methods
PubMed and EMBASE databases were searched for articles that compared the HRQOL scores,
Kansas City Cardiomyopathy Questionnaire (KCCQ), Medical Outcomes Study Short-Form
Health Survey 12 or 36 (SF-12/36), or the EuroQoL 5 Dimension score (EQ-5D) at 30 days and 1 year between TAVR and SAVR. Mean difference (MD) and 95% confidence interval (CI)
was calculated with inverse variance statistical method and random-effects model.
Results
A total of four studies with 4,125 patients (1268 transfemoral [TF]-TAVR, 1261 Non-TF
TAVR [transsubclavian, transapical or transaortic], and 1,596 SAVR) were included
in the studies. KCCQ overall summary scores and its subscales, SF-12/36, and EQ-5D
were significantly higher in TF-TAVR compared to SAVR but were similar in non-TF TAVR
vs. SAVR at 30 days. At 1-year follow-up, TF-TAVR and non-TF TAVR conferred similar
HRQOL scores in KCCQ overall summary and subscales scores, SF-12/36, and EQ-5D compared
to SAVR.
Conclusions
Transfermoral-TAVR achieved better HRQOL at 30 days but similar HRQOL at 1 year compared to SAVR. Non-TF TAVR resulted in similar improvements in HRQOL at both
30 days and 1 year compared with SAVR.
Keywords
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Article info
Publication history
Published online: August 16, 2018
Accepted:
July 25,
2018
Received in revised form:
July 6,
2018
Received:
March 12,
2018
Identification
Copyright
© 2018 Published by Elsevier B.V. on behalf of Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).