We read the article “Long-term follow-up of ground-glass nodules after 5 years of stability” that was recently published in the Journal of Thoracic Oncology. Lee et al. demonstrated that 13% of the included ground-glass nodules (GGN) showed growth after 5 years of stability in low-risk subjects during the natural course of GGN over 10 years [
]. In addition, bubble lucency, a history of cancer other than lung cancer and development of a new solid component were potential risk factors for predicting small GGN growth. This study demonstrated that small GGNs still have potential tendency to grow over 10 years, even after 5 years of stability. However, how to determine optimal surgical timing is difficult for these small GGNs with slow-growing behaviour in clinical practice.
- Lee H.W.
- Jin K.N.
- Lee J.K.
- Kim D.K.
- Chung H.S.
- Heo E.Y.
- et al.
Long-term follow-up of ground-glass nodules after 5 years of stability.
J Thorac Oncol. 2019; 14: 1370-1377
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- Long-term follow-up of ground-glass nodules after 5 years of stability.J Thorac Oncol. 2019; 14: 1370-1377
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Published online: March 20, 2020
Accepted: February 25, 2020
Received: January 27, 2020
© 2020 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.