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Heart, Lung and Circulation
Letter to the Editor| Volume 29, ISSUE 9, e254-e257, September 2020

Letter to the Editor Regarding “Long-Term Follow-Up of Ground-Glass Nodules After 5 Years of Stability.” by Lee et al., J Thorac Oncol 2019;14:1370–7

Published:March 20, 2020DOI:https://doi.org/10.1016/j.hlc.2020.02.010
      We read the article “Long-term follow-up of ground-glass nodules after 5 years of stability” that was recently published in the Journal of Thoracic Oncology. Lee et al. demonstrated that 13% of the included ground-glass nodules (GGN) showed growth after 5 years of stability in low-risk subjects during the natural course of GGN over 10 years [
      • Lee H.W.
      • Jin K.N.
      • Lee J.K.
      • Kim D.K.
      • Chung H.S.
      • Heo E.Y.
      • et al.
      Long-term follow-up of ground-glass nodules after 5 years of stability.
      ]. In addition, bubble lucency, a history of cancer other than lung cancer and development of a new solid component were potential risk factors for predicting small GGN growth. This study demonstrated that small GGNs still have potential tendency to grow over 10 years, even after 5 years of stability. However, how to determine optimal surgical timing is difficult for these small GGNs with slow-growing behaviour in clinical practice.
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