Aim
This study aimed to evaluate the association between serum myostatin levels, hospital
mortality, and muscle mass and strength following ST-segment elevation myocardial
infarction (STEMI).
Methods
This was a prospective observational study. Within 48 hours of admission, bioelectrical
impedance and handgrip strength were assessed and blood samples collected for myostatin
evaluation. Hospital mortality was recorded. A multiple logistic regression model
was also constructed, adjusted by parameters that exhibited significant differences
in the univariate analysis, to evaluate the association between myostatin levels and
hospital mortality.
Results
One hundred and two (102) patients were included: mean age was 60.5±10.6 years, 67.6%
were male, and 6.9% died during hospital stay. Univariate analysis showed that patients
with lower myostatin levels had higher mortality rates. Serum myostatin levels positively
correlated with handgrip strength (r=0.355; p<0.001) and appendicular skeletal muscle mass index (r=0.268; p=0.007). Receiver operating characteristic (ROC) curve analysis revealed
that lower myostatin levels were associated with hospital mortality at the <2.20 ng/mL
cut-off. Multiple logistic regression showed that higher serum myostatin levels were
associated with reduced hospital mortality when adjusted by β blocker use (OR, 0.228;
95% CI, 0.054–0.974; p=0.046).
Conclusions
Serum myostatin concentrations positively correlated with muscle mass and strength
in STEMI patients. Further assessment of serum myostatin association with mortality
should be conducted using a larger sample and assessing the additive value to the
Global Registry of Acute Coronary Events (GRACE) or thrombolysis in myocardial infarction
(TIMI) risk scores.
Keywords
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Article info
Publication history
Published online: September 28, 2021
Accepted:
August 22,
2021
Received in revised form:
August 14,
2021
Received:
May 7,
2021
Identification
Copyright
© 2021 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
