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Heart, Lung and Circulation

Time to Reconsider the Diagnosis of “Left Ventricular Noncompaction” in Adults?

  • Samantha Barratt Ross
    Affiliations
    Agnes Ginges Centre for Molecular Cardiology Centenary Institute, The University of Sydney, Sydney, NSW, Australia

    Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

    Wiser Healthcare, The University of Sydney, Sydney, NSW, Australia
    Search for articles by this author
  • Alexandra Barratt
    Affiliations
    Wiser Healthcare, The University of Sydney, Sydney, NSW, Australia

    Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
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  • Christopher Semsarian
    Correspondence
    Corresponding author at: Centenary Institute, Locked Bag 6, Newtown, NSW, 2042 Australia.
    Affiliations
    Agnes Ginges Centre for Molecular Cardiology Centenary Institute, The University of Sydney, Sydney, NSW, Australia

    Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

    Wiser Healthcare, The University of Sydney, Sydney, NSW, Australia

    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Search for articles by this author
Published:November 24, 2021DOI:https://doi.org/10.1016/j.hlc.2021.10.016
      Left ventricular non-compaction (LVNC) is characterised by a bi-layered myocardium, with excessive left ventricular (LV) trabeculation. Ongoing debate exists as to whether LVNC in adults is a distinct cardiomyopathy, or a morphological feature of ventricular remodelling present in physiological and pathological states. In this commentary, we explore how an increase in the diagnosis amongst the healthy adult population, in addition to cardiovascular cohorts and athletes [
      • Ross S.B.
      • Jones K.
      • Blanch B.
      • Puranik R.
      • McGeechan K.
      • Barratt A.
      • et al.
      A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults.
      ], has led to likely overdiagnosis or misdiagnosis—whereby a diagnosis leads to more harm than benefit. We propose a clinically meaningful diagnostic pathway to reduce these potential harms.

      Keywords

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