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Heart, Lung and Circulation

Poorer Self-Reported Physical Health and Higher Anxiety Trait in Young Adults With Previous Coarctation Repair

  • Melissa G.Y. Lee
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia

    Department of Medicine (RMH), University of Melbourne, Melbourne, Vic, Australia
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  • Taryn L. Luitingh
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
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  • Phillip S. Naimo
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
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  • Elisabeth Lambert
    Affiliations
    Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, Vic, Australia
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  • Michael M.H. Cheung
    Affiliations
    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia

    Department of Cardiology, The Royal Children’s Hospital, Melbourne, Vic, Australia
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  • Igor E. Konstantinov
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
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  • Christian P. Brizard
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia
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  • Gavin Lambert
    Affiliations
    Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, Vic, Australia
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  • Yves d’Udekem
    Correspondence
    Corresponding author at: Division of Cardiac Surgery, Children’s National Hospital, Washington, DC 20010, USA
    Affiliations
    Department of Cardiac Surgery, The Royal Children’s Hospital, Melbourne, Vic, Australia

    Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia

    Heart Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Vic, Australia

    Division of Cardiac Surgery, Children’s National Hospital, Washington, DC, USA
    Search for articles by this author
Published:January 19, 2022DOI:https://doi.org/10.1016/j.hlc.2021.12.003

      Background

      Little is known about the impact of a coarctation repair on the functional outcomes of young adults. This study aimed to determine (1) the functional and mental health status in young adults with previous coarctation repair, and (2) the impact of late hypertension on their quality of life.

      Methods

      A cross-sectional study using validated self-reported questionnaires (Short Form 36 version 2 [SF-36v2], Beck Depression Inventory [BDI], and State-Trait Anxiety Inventory [STAI]) was performed in 54 patients aged 15–47 years with previous paediatric coarctation repair. Questionnaire scores were compared to healthy age- and gender-matched controls. Patients’ previously published 24-hour blood pressure monitoring results were included.

      Results

      Late hypertension was present in 64% (34/54) at a mean of 29±8 years after coarctation repair. SF-36v2 mean physical component summary score was significantly lower in coarctation patients compared with controls (53.1±6.8 vs 56.0±4.7, p=0.02), but there was no significant difference in mean mental component summary score (p=0.2). SF-36v2 mean role emotional score tended to be associated with 10 mmHg increases in mean 24-hour systolic blood pressure (regression coefficient 4.3 p=0.06). STAI mean trait anxiety score tended to be higher in coarctation patients compared with controls (36.6±9.0 vs 33.5±7.8, p=0.06). There was no significant difference in BDI scores between patients and controls.

      Conclusions

      Young adults with previous coarctation repair report poorer physical health and tended towards higher anxiety trait compared to healthy controls. Strategies to improve self-reported physical health and anxiety should be explored. Long-term assessment of quality of life outcomes in coarctation patients is warranted.

      Keywords

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